Effects of apatite cements on proliferation and differentiation of human osteoblasts in vitro

Although apatite cement (AC) and sintered hydroxyapatite (s-HAP) are known to show good osteoconductivity, it is not clear whether or not the degree of their osteoconductivity is the same. In addition, it has not been clarified whether or not it is dependent on the type of AC; conventional AC (c-AC)...

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Bibliographic Details
Published in:Biomaterials 2004-03, Vol.25 (7), p.1159-1166
Main Authors: Yuasa, Tetsuya, Miyamoto, Youji, Ishikawa, Kunio, Takechi, Masaaki, Momota, Yukihiro, Tatehara, Seiko, Nagayama, Masaru
Format: Article
Language:English
Subjects:
Apatite cement
Biocompatible Materials - chemistry
Bone Cements - chemistry
Cell Adhesion - physiology
Cell attachment
Cell Differentiation - physiology
Cell Division - physiology
Cells, Cultured
Differentiation
Human osteoblasts
Humans
Hydroxyapatite
Hydroxyapatites - chemistry
Materials Testing
Molecular Conformation
Osseointegration - physiology
Osteoblasts - cytology
Osteoblasts - physiology
Proliferation
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Summary:Although apatite cement (AC) and sintered hydroxyapatite (s-HAP) are known to show good osteoconductivity, it is not clear whether or not the degree of their osteoconductivity is the same. In addition, it has not been clarified whether or not it is dependent on the type of AC; conventional AC (c-AC), fast-setting AC (fs-AC) or anti-washout AC (aw-AC). The aim of this study was to investigate the effects of ACs on cultured human osteoblasts, as they may provide a useful index of osteoconductivity. Human osteoblasts were cultured on the surfaces of ACs and s-HAP, and were evaluated with respect to cell attachment, proliferation, and differentiation. We found that ACs and s-HAP showed similar cell attachment. No significant difference between ACs and s-HAP was found with respect to the proliferation of osteoblasts. In contrast, we found that the differentiation of osteoblasts was enhanced on the surface of ACs compared with that of s-HAP. However, there was no difference among the types of AC. We therefore concluded that AC may show better osteoconductivity than s-HAP, and that osteoconductivity of AC may be similar, regardless of the type of AC.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2003.08.003