Kigamicins, Novel Antitumor Antibiotics: II. Structure Determination

Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of sixmembered rings and one oxazolidine....

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Bibliographic Details
Published in:Journal of antibiotics 2003/12/25, Vol.56(12), pp.1012-1017
Main Authors: KUNIMOTO, SETSUKO, SOMENO, TETSUYA, YAMAZAKI, YOHKO, LU, JIE, ESUMI, HIROYASU, NAGANAWA, HIROSHI
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - chemistry
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Doxorubicin - analogs & derivatives
Doxorubicin - chemistry
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Oxazoles - chemistry
Pharmacology. Drug treatments
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
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Summary:Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of sixmembered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.56.1012