Kigamicins, Novel Antitumor Antibiotics: II. Structure Determination

Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of sixmembered rings and one oxazolidine....

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 2003/12/25, Vol.56(12), pp.1012-1017
Main Authors: KUNIMOTO, SETSUKO, SOMENO, TETSUYA, YAMAZAKI, YOHKO, LU, JIE, ESUMI, HIROYASU, NAGANAWA, HIROSHI
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - chemistry
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Doxorubicin - analogs & derivatives
Doxorubicin - chemistry
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Oxazoles - chemistry
Pharmacology. Drug treatments
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c573t-5e0ed2de0d79939f91182824202f576b9c6b7ad550d08a46d5835abde705da3f3
cites
container_end_page 1017
container_issue 12
container_start_page 1012
container_title Journal of antibiotics
container_volume 56
creator KUNIMOTO, SETSUKO
SOMENO, TETSUYA
YAMAZAKI, YOHKO
LU, JIE
ESUMI, HIROYASU
NAGANAWA, HIROSHI
description Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of sixmembered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.
doi_str_mv 10.7164/antibiotics.56.1012
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71554846</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71554846</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-5e0ed2de0d79939f91182824202f576b9c6b7ad550d08a46d5835abde705da3f3</originalsourceid><addsrcrecordid>eNqFkDlPxDAQhS0EguX4BUiIBmjIMmPHR0qEuMRqaaC2HNsBoxxgZ5H492TZCLajmZnim_eeHiGHCFOJIr8wbR_K0PXBpikXUwSkG2SCSmGGuSg2yQSAYqYUhR2ym9IbAJNMqm2ygxyQS6om5OwhvJgm2NCm8-N59-nr48tBt180Xfy5Rod9slWZOvmDce-R55vrp6u7bPZ4e391Ocssl6zPuAfvqPPgZFGwoioQFVU0p0ArLkVZWFFK4zgHB8rkwnHFuCmdl8CdYRXbI6cr3ffYfSx86nUTkvV1bVrfLZKWyHmucvEviAqEkBwGkK1AG7uUoq_0ewyNiV8aQS-L1GtFai70ssjh62iUX5SNd38_Y3MDcDICJllTV9G0NqQ1jiMV-dJ-vuLeUm9e_C9g4uBX-3VzLIT6CUDHuUzyC9pXE7Vv2TcAAZkQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18066750</pqid></control><display><type>article</type><title>Kigamicins, Novel Antitumor Antibiotics: II. Structure Determination</title><source>J-STAGE (Japan Science &amp; Technology Information Aggregator, Electronic) - Open Access English articles</source><creator>KUNIMOTO, SETSUKO ; SOMENO, TETSUYA ; YAMAZAKI, YOHKO ; LU, JIE ; ESUMI, HIROYASU ; NAGANAWA, HIROSHI</creator><creatorcontrib>KUNIMOTO, SETSUKO ; SOMENO, TETSUYA ; YAMAZAKI, YOHKO ; LU, JIE ; ESUMI, HIROYASU ; NAGANAWA, HIROSHI</creatorcontrib><description>Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of sixmembered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.56.1012</identifier><identifier>PMID: 15015728</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Antibiotics, Antineoplastic - chemistry ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Doxorubicin - analogs &amp; derivatives ; Doxorubicin - chemistry ; Magnetic Resonance Spectroscopy ; Medical sciences ; Molecular Structure ; Oxazoles - chemistry ; Pharmacology. Drug treatments ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet</subject><ispartof>The Journal of Antibiotics, 2003/12/25, Vol.56(12), pp.1012-1017</ispartof><rights>Japan Antibiotics Research Association</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-5e0ed2de0d79939f91182824202f576b9c6b7ad550d08a46d5835abde705da3f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=15512640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15015728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUNIMOTO, SETSUKO</creatorcontrib><creatorcontrib>SOMENO, TETSUYA</creatorcontrib><creatorcontrib>YAMAZAKI, YOHKO</creatorcontrib><creatorcontrib>LU, JIE</creatorcontrib><creatorcontrib>ESUMI, HIROYASU</creatorcontrib><creatorcontrib>NAGANAWA, HIROSHI</creatorcontrib><title>Kigamicins, Novel Antitumor Antibiotics: II. Structure Determination</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of sixmembered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.</description><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Doxorubicin - analogs &amp; derivatives</subject><subject>Doxorubicin - chemistry</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Oxazoles - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Spectrophotometry, Infrared</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkDlPxDAQhS0EguX4BUiIBmjIMmPHR0qEuMRqaaC2HNsBoxxgZ5H492TZCLajmZnim_eeHiGHCFOJIr8wbR_K0PXBpikXUwSkG2SCSmGGuSg2yQSAYqYUhR2ym9IbAJNMqm2ygxyQS6om5OwhvJgm2NCm8-N59-nr48tBt180Xfy5Rod9slWZOvmDce-R55vrp6u7bPZ4e391Ocssl6zPuAfvqPPgZFGwoioQFVU0p0ArLkVZWFFK4zgHB8rkwnHFuCmdl8CdYRXbI6cr3ffYfSx86nUTkvV1bVrfLZKWyHmucvEviAqEkBwGkK1AG7uUoq_0ewyNiV8aQS-L1GtFai70ssjh62iUX5SNd38_Y3MDcDICJllTV9G0NqQ1jiMV-dJ-vuLeUm9e_C9g4uBX-3VzLIT6CUDHuUzyC9pXE7Vv2TcAAZkQ</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>KUNIMOTO, SETSUKO</creator><creator>SOMENO, TETSUYA</creator><creator>YAMAZAKI, YOHKO</creator><creator>LU, JIE</creator><creator>ESUMI, HIROYASU</creator><creator>NAGANAWA, HIROSHI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Kigamicins, Novel Antitumor Antibiotics</title><author>KUNIMOTO, SETSUKO ; SOMENO, TETSUYA ; YAMAZAKI, YOHKO ; LU, JIE ; ESUMI, HIROYASU ; NAGANAWA, HIROSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-5e0ed2de0d79939f91182824202f576b9c6b7ad550d08a46d5835abde705da3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Doxorubicin - analogs &amp; derivatives</topic><topic>Doxorubicin - chemistry</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Oxazoles - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Spectrophotometry, Infrared</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUNIMOTO, SETSUKO</creatorcontrib><creatorcontrib>SOMENO, TETSUYA</creatorcontrib><creatorcontrib>YAMAZAKI, YOHKO</creatorcontrib><creatorcontrib>LU, JIE</creatorcontrib><creatorcontrib>ESUMI, HIROYASU</creatorcontrib><creatorcontrib>NAGANAWA, HIROSHI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUNIMOTO, SETSUKO</au><au>SOMENO, TETSUYA</au><au>YAMAZAKI, YOHKO</au><au>LU, JIE</au><au>ESUMI, HIROYASU</au><au>NAGANAWA, HIROSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kigamicins, Novel Antitumor Antibiotics: II. Structure Determination</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>56</volume><issue>12</issue><spage>1012</spage><epage>1017</epage><pages>1012-1017</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of sixmembered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>15015728</pmid><doi>10.7164/antibiotics.56.1012</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0021-8820
ispartof The Journal of Antibiotics, 2003/12/25, Vol.56(12), pp.1012-1017
issn 0021-8820
1881-1469
language eng
recordid cdi_proquest_miscellaneous_71554846
source J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles
subjects Antibiotics, Antineoplastic - chemistry
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Doxorubicin - analogs & derivatives
Doxorubicin - chemistry
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Oxazoles - chemistry
Pharmacology. Drug treatments
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
title Kigamicins, Novel Antitumor Antibiotics: II. Structure Determination
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T05%3A38%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Kigamicins,%20Novel%20Antitumor%20Antibiotics:%20II.%20Structure%20Determination&rft.jtitle=Journal%20of%20antibiotics&rft.au=KUNIMOTO,%20SETSUKO&rft.date=2003-12-01&rft.volume=56&rft.issue=12&rft.spage=1012&rft.epage=1017&rft.pages=1012-1017&rft.issn=0021-8820&rft.eissn=1881-1469&rft.coden=JANTAJ&rft_id=info:doi/10.7164/antibiotics.56.1012&rft_dat=%3Cproquest_cross%3E71554846%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c573t-5e0ed2de0d79939f91182824202f576b9c6b7ad550d08a46d5835abde705da3f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=18066750&rft_id=info:pmid/15015728&rfr_iscdi=true