Substituted indoloquinolines as new antifungal agents

Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms. A number of 2-substitute...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2002-05, Vol.10 (5), p.1337-1346
Main Authors: ABLORDEPPEY, Seth Y, PINGCHEN FAN, SHOUMING LI, CLARK, Alice M, HUFFORD, Charles D
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biological and medical sciences
Indole Alkaloids
Indoles - chemical synthesis
Indoles - chemistry
Indoles - pharmacology
Medical sciences
Microbial Sensitivity Tests
Mitosporic Fungi - drug effects
Pharmacology. Drug treatments
Quinolines - chemical synthesis
Quinolines - chemistry
Quinolines - pharmacology
Structure-Activity Relationship
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms. A number of 2-substituted indoloquinolines have been synthesized and evaluated in antifungal screens and several have been shown to increase potency and expand the antifungal spectrum of cryptolepine. Comparison of MICs of a number of these analogues with standard antifungal agents, shows them to be comparable to Amphotericin B and Ketoconazole.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(01)00401-1