The effect of fast reporting by amnio-PCR on anxiety levels in women with positive biochemical screening for Down syndrome - a randomized controlled trial

Objective To study the effect of fast reporting by polymerase chain reaction on amniotic fluid cells (amnio‐PCR) on anxiety levels in women with positive biochemical screening for Down syndrome. Method Between May 2000 and April 2001, 60 screen‐positive women were randomized before amniocentesis int...

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Bibliographic Details
Published in:Prenatal diagnosis 2002-03, Vol.22 (3), p.256-259
Main Authors: Cheong Leung, Wing, Hang Lam, Yung, Wong, Ying, T. Lau, Elizabeth, Hoi Yin Tang, Mary
Format: Article
Language:English
Subjects:
Adult
Amniocentesis
Amniotic Fluid - cytology
Anxiety
Biological and medical sciences
Down syndrome
Down Syndrome - diagnosis
Down Syndrome - genetics
Female
Gynecology. Andrology. Obstetrics
Humans
Karyotyping
Management. Prenatal diagnosis
Maternal Age
Medical sciences
Polymerase Chain Reaction
Pregnancy
Pregnancy, High-Risk
Pregnancy. Fetus. Placenta
Prenatal Diagnosis - psychology
screening
STAI
Surveys and Questionnaires
Time Factors
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Summary:Objective To study the effect of fast reporting by polymerase chain reaction on amniotic fluid cells (amnio‐PCR) on anxiety levels in women with positive biochemical screening for Down syndrome. Method Between May 2000 and April 2001, 60 screen‐positive women were randomized before amniocentesis into either having (group A) or not having (group B) fast‐reporting by amnio‐PCR. Anxiety levels were measured by the Spielberger State‐Trait Anxiety Inventory just prior to amniocentesis, three days (when PCR results were known to group A) and three weeks (when standard karyotype results were known to both groups) afterwards. Results Two women were excluded because in one woman amnio‐PCR showed trisomy 21 and the other miscarried shortly after amniocentesis. The state‐anxiety scores increased over the three‐week period after being informed of the positive‐screen result in both groups. The trait‐ and state‐anxiety scores at all points did not differ between the two groups. Conclusions In contrast to the general belief, fast reporting by amnio‐PCR did not alleviate anxiety in women who are screen‐positive for Down syndrome. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.314