The chemokine receptor, CCR5

The chemokine receptor, CCR5, is a G protein coupled receptor responsible for some of the effects of the chemokines CCL3, CCL4 and CCL5. It is also one of the co-receptors for the entry of human immunodeficiency virus-1 (HIV-1) into cells. Regulation of CCR5 number on cells is, therefore, important...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2004, Vol.36 (1), p.35-38
Main Authors: Mueller, Anja, Strange, Philip G
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
CCR5
Chemokine receptors
Chromosomes, Human, Pair 3
Drug action
Frameshift Mutation
Function
Gene Frequency
HIV Infections - immunology
HIV-1
HIV-1 - immunology
Humans
Polymorphism, Genetic
Protein Structure, Secondary
Receptors, CCR5 - chemistry
Receptors, CCR5 - genetics
Receptors, CCR5 - immunology
Receptors, CCR5 - physiology
Structure
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Summary:The chemokine receptor, CCR5, is a G protein coupled receptor responsible for some of the effects of the chemokines CCL3, CCL4 and CCL5. It is also one of the co-receptors for the entry of human immunodeficiency virus-1 (HIV-1) into cells. Regulation of CCR5 number on cells is, therefore, important for determining the infection rate by HIV-1.
ISSN:1357-2725
1878-5875
DOI:10.1016/S1357-2725(03)00172-9