Smoking impact on CYP1A2 activity in a group of patients with schizophrenia

The purpose of the present study was to assess the impact of smoking on the metabolism of psychotropic drugs in a group of patients with schizophrenia, by measuring CYP1A2 activity. This activity was assessed by the molar ratio (MR) of caffeine metabolites in urine [(AFMU+1U+1X)/17U] and saliva (17X...

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Bibliographic Details
Published in:European neuropsychopharmacology 2004, Vol.14 (1), p.39-44
Main Authors: Bozikas, Vasilis P., Papakosta, Maria, Niopas, Ioannis, Karavatos, Athanasios, Mirtsou-Fidani, Vasiliki
Format: Article
Language:English
Subjects:
Adult
Aged
Antipsychotic Agents - blood
Antipsychotic Agents - urine
Caffeine - metabolism
Chi-Square Distribution
Cytochrome P-450 CYP1A2 - blood
Cytochrome P-450 CYP1A2 - metabolism
Cytochrome P-450 CYP1A2 - urine
Enzyme Activation - physiology
Female
Humans
Male
Middle Aged
Schizophrenia - blood
Schizophrenia - enzymology
Schizophrenia - urine
Sex Factors
Smoking - blood
Smoking - metabolism
Smoking - urine
Statistics, Nonparametric
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Summary:The purpose of the present study was to assess the impact of smoking on the metabolism of psychotropic drugs in a group of patients with schizophrenia, by measuring CYP1A2 activity. This activity was assessed by the molar ratio (MR) of caffeine metabolites in urine [(AFMU+1U+1X)/17U] and saliva (17X/137X). Participants were 40 patients with schizophrenia: 30 current cigarette smokers and 10 nonsmokers. The two groups (smokers and nonsmokers) differed significantly in their ratio of men to women (83% men and 17% women were among smokers compared with 50% men and 50% women nonsmokers). No other group differences were found regarding age, level of education, PANSS, extrapyramidal symptoms, age of symptoms onset, antipsychotic doses (chloropromazine equivalents), and anticholinergic drug used. Smokers had significant higher MR in urine ( P
ISSN:0924-977X
1873-7862
DOI:10.1016/S0924-977X(03)00061-0