Significance of 8-hydroxy-2′-deoxyguanosine levels in patients with chronic renal failure

The aim of this study was to determine the significance of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), which is known as a marker of oxidative stress in vivo, in patients with chronic renal failure (CRF). Fifty‐one non‐dialysed CRF patients (29 men and 22 women; mean ± SD age, 57.8 ± 12.8 years) who were...

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Published in:Nephrology (Carlton, Vic.) Vic.), 2003-08, Vol.8 (4), p.192-195
Main Authors: AKAGI, Shigeru, NAGAKE, Yoshio, KASAHARA, Junko, SARAI, Ai, KIHARA, Takashi, MORIMOTO, Hisanori, YANO, Ai, NAKAO, Kazushi, NANBA, Kiyohito, ICHIKAWA, Haruo, MAKINO, Hirofumi
Format: Article
Language:English
Subjects:
8-hydroxy-2′-deoxyguanosine
chronic renal failure
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
Female
Humans
Kidney Failure, Chronic - metabolism
Male
Middle Aged
oxidative stress
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Summary:The aim of this study was to determine the significance of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), which is known as a marker of oxidative stress in vivo, in patients with chronic renal failure (CRF). Fifty‐one non‐dialysed CRF patients (29 men and 22 women; mean ± SD age, 57.8 ± 12.8 years) who were under dietary therapy for at least 6 months were enrolled in the study. Both serum and urinary 8‐OHdG levels were measured by using high‐sensitive enzyme‐linked immunosorbent assay (ELISA) kits. We examined the relationship between 8‐OHdG levels and clinical indices in patients with CRF. As a result, the serum 8‐OHdG level was strongly correlated with serum levels of urea nitrogen (UN; r = 0.58; P 
ISSN:1320-5358
1440-1797
DOI:10.1046/j.1440-1797.2003.00163.x