Pulmonary inflammatory mediators after sevoflurane and thiopentone anaesthesia in pigs

• Published in: Acta anaesthesiologica Scandinavica 2004-01, Vol.48 (1), p.40-45
• Main Authors: Takala, R. S. K., Soukka, H. R., Salo, M. S., Kirvelä, O. A., Kääpä, P. O., Rajamäki, A. A., Riutta, A., Aantaa, R. E.
• Format: Article
• Language: English
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Inhalation - pharmacology; Anesthetics, Intravenous - pharmacology; Animals; Biological and medical sciences; Bronchoalveolar lavage; Bronchoalveolar Lavage Fluid - chemistry; Bronchoalveolar Lavage Fluid - cytology; Cytokines - biosynthesis; eicosanoids; Eicosanoids - biosynthesis; Female; inflammation; Inflammation Mediators - metabolism; Leukocyte Count; Leukotriene C4 - biosynthesis; Lung - drug effects; Lung - metabolism; Male; Medical sciences; Methyl Ethers - pharmacology; Nitric Oxide - biosynthesis; nitric oxide. volatile anaesthetics; Sevoflurane; Swine; Thiopental - pharmacology
• ISSN: 0001-5172; 1399-6576
• DOI: 10.1111/j.1399-6576.2004.00266.x

Background:  Volatile anaesthetics have been shown to affect the release of pulmonary inflammatory mediators and exacerbate pulmonary injury after experimental aspiration. Thus, in theory, volatile anaesthetics may worsen inflammatory pulmonary injury and disease. We have previously described that no significant changes in alveolar ultrastructure are seen after sevoflurane anaesthesia. However, this does not exclude any possible physiological alterations. The aim of our study was to evaluate pulmonary inflammatory mediators in bronchoalveolar lavage (BAL) after sevoflurane and thiopentone anaesthesia in pigs with intact lungs. Methods:  Sixteen pigs were randomly selected to receive either a continuous thiopentone infusion (control group, n = 8) or sevoflurane (n = 8) at 4.0% inspiratory concentration (1.5 MAC) in air for 6 h. Bronchoalveolar lavage samples were collected at the end of the study to determine pulmonary inflammatory markers. Results:  Compared with thiopentone anaesthesia, significant increases in BAL leukotriene C4 (LTC4), NO3‐, and NO2‐ levels were observed after sevoflurane anaesthesia. In addition, there was a significant decrease in total blood leukocyte count in sevoflurane‐treated animals. Conclusion:  We conclude that sevoflurane increases pulmonary LTC4, NO3‐, and NO2‐ production in pigs, indicating an inflammatory response.