Does exercise-induced severe ischaemia result in elevation of plasma troponin-T level in patients with chronic coronary artery disease?

• Published in: Acta Cardiologica 2002-02, Vol.57 (1), p.13-18
• Main Authors: Akdemir, Ilyas, Aksoy, Nur, Aksoy, Mehmet, Davutoglu, Vedat, Dinckal, Hakan
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Cardiology. Vascular system; chronic coronary disease; Chronic Disease; Coronary Disease - blood; Coronary heart disease; Exercise Test; Female; Heart; Humans; Male; Medical sciences; Middle Aged; Myocardial Ischemia - blood; Myocardial Ischemia - diagnostic imaging; myocardial perfusion imaging; Prospective Studies; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; troponin T; Troponin T - blood
• ISSN: 0001-5385; 0373-7934; 1784-973X; 0001-5385
• DOI: 10.2143/AC.57.1.2005373

Objective - It has been reported that the loss of cell membrane integrity during severe reversible ischaemia results in elevation of plasma troponin T (TnT) in unstable angina.We investigated whether TnT is released into circulation during severe ischaemia (e.g. on treadmill exercise testing) in patients with chronic coronary artery disease (CAD). Methods and results - The study comprised 54 patients who had angiographically documented CAD (22 of them had a prior history of myocardial infarction) and 18 normal subjects. All cases underwent exercise thallium (Tl)-201 SPECT myocardial perfusion imaging. Blood samples for TnT analysis were obtained for each patient at pre-exercise, immediately after and 12 hours after exercise. SPECT images were divided into 20 segments. Patients with redistribution defects ≥ 5 were considered to have severe ischaemia. Sixteen patients had severe ischaemia on SPECT images. The mean TnT levels of the patients with severe ischaemia at pre-exercise, immediately after and 12 hours after exercise were 0.009 ± 0.008, 0.012 ± 0.009 and 0.010 ± 0.010 ng/ml, respectively. In normal subjects the mean TnT levels were 0.012 ± 0.009, 0.010 ± 0.009, 0.010 ± 0.010 ng/ml, respectively.There was no significant difference neither between the two groups nor within each group with respect to pre-exercise and post-exercise TnT results. All TnT levels were within normal limits (< 0.1 ng/dl). Additionally, when the patients were grouped according to other SPECT variables (patients with reversible defects vs. fixed defects; patients with increased lung uptake of Tl-201 vs. without lung uptake; patients with transient left ventricle dilatation vs. those without) and angiographic findings (patients with multivessel disease vs. normal subjects), there were no significant differences with respect to pre-exercise and post-exercise TnT results. Conclusion - Severe ischaemia does not result in the elevation of the plasma TnT level in patients with chronic CAD.