Increased Plasma HB-EGF Associated with Obesity and Coronary Artery Disease

The mechanism by which the obese subjects are more associated with vascular disease remains unclear. We reported that the adipose tissues produce and secrete many bioactive molecules, conceptualized as adipocytokines. Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), produce...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2002-04, Vol.292 (3), p.781-786
Main Authors: Matsumoto, Satoru, Kishida, Ken, Shimomura, Iichiro, Maeda, Norikazu, Nagaretani, Hiroyuki, Matsuda, Morihiro, Nishizawa, Hitoshi, Kihara, Shinji, Funahashi, Tohru, Matsuzawa, Yuji
Format: Article
Language:English
Subjects:
adipocytokines
Adipose Tissue - metabolism
Adult
Aged
Animals
atherosclerosis
coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - physiopathology
Epidermal Growth Factor - blood
Epidermal Growth Factor - genetics
HB-EGF
Heparin-binding EGF-like Growth Factor
Humans
Intercellular Signaling Peptides and Proteins
Male
Mice
Mice, Obese
Middle Aged
obesity
Obesity - blood
Obesity - physiopathology
RNA - metabolism
Statistics as Topic
Tissue Distribution
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Summary:The mechanism by which the obese subjects are more associated with vascular disease remains unclear. We reported that the adipose tissues produce and secrete many bioactive molecules, conceptualized as adipocytokines. Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), produced locally by vascular macrophages and smooth muscle cells, has been suggested to induce the migration and proliferation of vascular smooth muscle cells. The current study reveals that (1) HB-EGF mRNA is abundantly expressed in human adipose tissue, (2) HB-EGF mRNA increases in the fat tissues of obese mice, (3) plasma HB-EGF levels increase in parallel with fat accumulation in human, and (4) the subjects with coronary artery disease have higher plasma HB-EGF levels, associated with fat accumulation. These results suggest that increased plasma HB-EGF derived from the accumulated fat contributes to the higher incidence of vascular disease in obesity, proposing HB-EGF as an adipocytokine directly linking adipovascular axis.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.2002.6720