Early Activation and Induction of Apoptosis in T Cells Is Independent of c-Fos

: We used c‐Fos‐deficient activated T cells from the spleen and c‐Fos‐deficient thymocytes to address the capacity of these cells to undergo apoptosis in response to various stimuli. To determine the role of c‐Fos in apoptosis regulation in thymocytes, we challenged thymocytes from wild‐type and c‐F...

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Published in:Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.225-231, Article 225
Main Authors: BIERBAUM, HANNA, BAUMANN, SVEN, HERR, INGRID, TUCKERMANN, JAN P., HESS, JOCHEN, SCHORPP-KISTNER, MARINA, ANGEL, PETER
Format: Article
Language:English
Subjects:
Animals
apoptosis
c-Fos
Concanavalin A - pharmacology
early activation
Genes, fos
Humans
induction
Lymphocyte Activation - drug effects
Mice
Proto-Oncogene Proteins c-fos - physiology
Spleen - cytology
Spleen - physiology
T cells
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
T-Lymphocytes - physiology
Thymus Gland - cytology
Thymus Gland - physiology
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Summary:: We used c‐Fos‐deficient activated T cells from the spleen and c‐Fos‐deficient thymocytes to address the capacity of these cells to undergo apoptosis in response to various stimuli. To determine the role of c‐Fos in apoptosis regulation in thymocytes, we challenged thymocytes from wild‐type and c‐Fos‐deficient mice with either TPA or the glucocorticoid dexamethasone. After various time points cells were stained according to the Nicoletti method and analyzed by FACS. Thymocytes from both genotypes exhibited similar efficiency of apoptosis in response to treatment with TPA or dexamethasone. Our data provide clear evidence that c‐Fos is not required for apoptosis regulation in activated T cells as well as in thymocytes.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1299.040