Human papillomavirus, p53 and Cyclin D1 expression in oropharyngeal carcinoma

Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which co...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2003-10, Vol.32 (5), p.539-543
Main Authors: Kumar, R.V., Kadkol, S.S., Daniel, R., Shenoy, A.M., Shah, K.V.
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - virology
cyclin
Cyclin D1 - metabolism
Dentistry
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Male
Oncogene Proteins, Viral - metabolism
Oropharyngeal Neoplasms - metabolism
Oropharyngeal Neoplasms - virology
oropharynx
papiIlomaviruses
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
protein p53
Tongue Neoplasms - metabolism
Tongue Neoplasms - virology
tonsillar neoplasms
Tonsillar Neoplasms - metabolism
Tonsillar Neoplasms - virology
Tumor Suppressor Protein p53 - metabolism
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Summary:Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression ( P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.
ISSN:0901-5027
1399-0020
DOI:10.1016/S0901-5027(03)90407-8