Humoral autoimmune responses to neurospecific proteins in rats with experimental allergic encephalomyelitis and immunomodulation with allogeneic nervous tissue

Possible immunocorrective effect of the embryonic nervous tissue (NT) and using the model of an experimental allergic encephalomyelitis (EAE) in treating patients with demyelinizing diseases is a prospective field of research. EAE was induced by immunization of rats with the mixture of the spinal co...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2002, Vol.48 (1), p.15-24
Main Authors: Lisianyĭ, M I, Liubych, L D, Markova, O V, Biel's'ka, L M
Format: Article
Language:Ukrainian
Subjects:
Animals
Animals, Newborn
Autoantibodies - blood
Autoantibodies - immunology
Brain - cytology
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - physiopathology
Immunotherapy
Myelin Basic Protein - immunology
Neuroglia - immunology
Neuroglia - transplantation
Neurons - immunology
Neurons - transplantation
Rats
Transplantation, Homologous
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Summary:Possible immunocorrective effect of the embryonic nervous tissue (NT) and using the model of an experimental allergic encephalomyelitis (EAE) in treating patients with demyelinizing diseases is a prospective field of research. EAE was induced by immunization of rats with the mixture of the spinal cord and BCV at paw pillows. Immunocorrective effect of the allogenic NT was studied in the animals with EAE following the intraperitoneal injection of a newborn rat's NT, namely: enriched fractions of glial and neuronal cell populations. Both intact and EAE animals, treated with culture medium, were used as controls. The clinical signs appeared on 12-th day after EAE inducing. The severe clinical course of EAE was accompanied with statistically significant higher titers of the autoantibodies to MBP as compared with the mild clinical course. The results obtained evidence for the possible immunocorrective effect of enriched fractions of the newborn rat's nervous cells on EAE, and for immunosuppressive effect of the neuronal fraction of NT on the immunopathological processes in EAE.
ISSN:2522-9028