IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells

The IRTA1 and IRTA2 genes encode immunoglobulinlike cell surface receptors expressed in B cells and involved in chromosome 1q21 translocations in B-cell malignancy. We have now characterized and comparatively analyzed the structure and expression pattern of the entire family of IRTA genes, which inc...

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Bibliographic Details
Published in:Blood 2002-04, Vol.99 (8), p.2662-2669
Main Authors: Miller, Ira, Hatzivassiliou, Georgia, Cattoretti, Giorgio, Mendelsohn, Cathy, Dalla-Favera, Riccardo
Format: Article
Language:English
Subjects:
Amino Acid Sequence
B-Lymphocytes - metabolism
B-Lymphocytes - pathology
Biological and medical sciences
Cell Compartmentation
Chromosome Mapping
Chromosomes, Human, Pair 1 - genetics
Conserved Sequence
Gene Expression Regulation
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Molecular Sequence Data
Multigene Family - genetics
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Receptors, Fc
Receptors, IgG - genetics
Receptors, Immunologic
RNA, Messenger - metabolism
Sequence Alignment
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Summary:The IRTA1 and IRTA2 genes encode immunoglobulinlike cell surface receptors expressed in B cells and involved in chromosome 1q21 translocations in B-cell malignancy. We have now characterized and comparatively analyzed the structure and expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome 1q21. The IRTA messenger RNAs are expressed predominantly in the B-cell lineage within discrete B-cell compartments: IRTA1 is specific to the marginal zone, IRTA2 and IRTA3 are found in the germinal center light zone and in intraepithelial and interfollicular regions, and IRTA4 and IRTA5 are expressed predominantly in the mantle zone. All IRTA genes code for transmembrane receptors that are closely related to Fc receptors in their most amino-terminal extracellular domains and that possess cytoplasmic domains containing ITIM (immunotyrosine inhibition motifs)– and, possibly, ITAM (immunotyrosine activation motifs)–like motifs. These structural features suggest that the IRTA receptors may play a role in regulating activation of normal B cells and possibly in the development of neoplasia.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V99.8.2662