Rig-1 a new member of Robo family genes exhibits distinct pattern of expression during mouse development

The Robo genes encode a family of proteins that are the receptors for the midline repellent Slits and play a role in axon guidance. In addition to Robo1 and Robo2, Rig-1 has been recently identified in mouse as a novel member of the Robo family of proteins. As a first step in elucidating the role of...

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Bibliographic Details
Published in:Gene Expression Patterns 2004, Vol.4 (1), p.99-103
Main Authors: Camurri, Laura, Mambetisaeva, Elvira, Sundaresan, Vasi
Format: Article
Language:English
Subjects:
Animals
Brain - embryology
Brain - metabolism
Embryo, Mammalian - embryology
Embryo, Mammalian - metabolism
Gene Expression Profiling
Gene Expression Regulation, Developmental
In Situ Hybridization
Membrane Proteins - genetics
Mice
Mouse embryo
Nerve Tissue Proteins - genetics
Receptors, Cell Surface
Receptors, Immunologic - genetics
Rig-1
Rig-1 gene
Robo1 gene
Robo1/DUTT1
Robo2 gene
Roundabout Proteins
Spinal cord
Spinal Cord - embryology
Spinal Cord - metabolism
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Summary:The Robo genes encode a family of proteins that are the receptors for the midline repellent Slits and play a role in axon guidance. In addition to Robo1 and Robo2, Rig-1 has been recently identified in mouse as a novel member of the Robo family of proteins. As a first step in elucidating the role of Rig-1 during vertebrate development, we characterised the expression of Rig-1 by in situ hybridisation together with Robo1 and Robo2 in the spinal cord and other tissues of the mouse embryo. Our results show that Rig-1 has a dynamic pattern of expression in the developing CNS. In the spinal cord Rig-1 shows overlapping but distinct pattern of expression with Robo1 and Robo2.
ISSN:1567-133X
1872-7298
DOI:10.1016/S1567-133X(03)00142-X