Response to paclitaxel and carboplatin in metastatic salivary gland cancer: A case report

Background Malignant tumors of the salivary gland are rare entities that are treated primarily by surgical resection. For patients with recurrent or unresectable disease, options include radiation therapy or chemotherapy; however, responses are few and of short duration. Patients with metastatic dis...

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Bibliographic Details
Published in:Head & neck 2002-04, Vol.24 (4), p.406-410
Main Authors: Ruzich, Janet C., Ciesla, Marlyn C., Clark, Joseph I.
Format: Article
Language:English
Subjects:
adenocarcinoma
Adenocarcinoma - drug therapy
Adenocarcinoma - secondary
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
carboplatin
Carboplatin - therapeutic use
Chemotherapy
Humans
Male
Medical sciences
metastatic
Middle Aged
Otorhinolaryngology. Stomatology
paclitaxel
Paclitaxel - therapeutic use
Pharmacology. Drug treatments
salivary gland cancer
Salivary Gland Neoplasms - drug therapy
Salivary Gland Neoplasms - secondary
Treatment Outcome
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background Malignant tumors of the salivary gland are rare entities that are treated primarily by surgical resection. For patients with recurrent or unresectable disease, options include radiation therapy or chemotherapy; however, responses are few and of short duration. Patients with metastatic disease have been treated with chemotherapy, but, again, response rates have been low and of short duration. Methods A 52‐year‐old man was seen with a mass on his tongue. A biopsy revealed adenocarcinoma of a minor salivary gland. Ten months after surgical resection, neck dissection, and radiation therapy, the patient was found to have metastatic disease to the lung. Chemotherapy was initiated with carboplatin and paclitaxel. Results The patient obtained a complete response after six cycles of carboplatin and paclitaxel. Conclusions The use of carboplatin and paclitaxel in the setting of metastatic salivary gland cancer is a viable option. © 2002 Wiley Periodicals, Inc. Head Neck 24: 406–410, 2002
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.10034