Stimulation of local antibody production: parenteral or mucosal vaccination?

Mucosal vaccines aim to prevent the penetration of pathogens, including HIV, into the body. Their cost can be low compared with curative therapies and thus, they are well suited to the fight against pandemic diseases in developing countries. Efficacy has been demonstrated for the oral poliovirus vac...

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Bibliographic Details
Published in:Trends in Immunology 2002-04, Vol.23 (4), p.209-213
Main Authors: Bouvet, Jean-Pierre, Decroix, Nipa, Pamonsinlapatham, Perayot
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - pharmacology
Bacterial Vaccines - administration & dosage
Bacterial Vaccines - immunology
Human immunodeficiency virus
Humans
humoral
IgG
Immune system
Immunity, Active
Immunity, Mucosal
M cells
MALT, Peyer's patches
Microorganisms
Models, Immunological
mucosa-associated lymphoid tissue
mucosal
Mucous Membrane - drug effects
Mucous Membrane - immunology
Mucous Membrane - microbiology
parenteral
Rodents
secretory IgA
Studies
vaccination
Vaccination - methods
Vaccines
Vaccines - administration & dosage
Vaccines - immunology
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
Viral Vaccines - administration & dosage
Viral Vaccines - immunology
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Summary:Mucosal vaccines aim to prevent the penetration of pathogens, including HIV, into the body. Their cost can be low compared with curative therapies and thus, they are well suited to the fight against pandemic diseases in developing countries. Efficacy has been demonstrated for the oral poliovirus vaccine, but only very few other vaccines administered by the mucosal route are available commercially at present. Tremendous research efforts have now improved significantly the classical approach of these vaccines, and alternative methods of immunization, based on new concepts of mucosal immunity, are being developed. Mucosal administration is not the only method of mucosal vaccination.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(02)02186-5