The association of HLA with young-onset keratoconus in Japan

PURPOSE: To report the association of HLA antigens with keratoconus in Japanese patients. DESIGN: Observational consecutive case series. METHODS: In 90 consecutive Japanese keratoconus patients, HLA class I (HLA-A, -B, -C) and class II (HLA-DR, -DQ) were analyzed. RESULTS: Compared with control freq...

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Bibliographic Details
Published in:American journal of ophthalmology 2002-04, Vol.133 (4), p.557-559
Main Authors: Adachi, Wakako, Mitsuishi, Yoko, Terai, Kazuto, Nakayama, Chisato, Hyakutake, Yoko, Yokoyama, Junko, Mochida, Chikako, Kinoshita, Shigeru
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Biological and medical sciences
Child
Diseases of cornea, anterior segment and sclera
Female
Gene Frequency
Genes, MHC Class I
Genes, MHC Class II
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class II - genetics
Humans
Japan - epidemiology
Keratoconus - ethnology
Keratoconus - genetics
Male
Medical sciences
Middle Aged
Oculomotor disorders
Ophthalmology
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Summary:PURPOSE: To report the association of HLA antigens with keratoconus in Japanese patients. DESIGN: Observational consecutive case series. METHODS: In 90 consecutive Japanese keratoconus patients, HLA class I (HLA-A, -B, -C) and class II (HLA-DR, -DQ) were analyzed. RESULTS: Compared with control frequencies, based on mean gene frequencies for the Japanese population, higher frequencies of HLA-A26, B40, and DR9 antigens were found in patients whose conditions were diagnosed before 20 years of age (χ 2 = 6.45, P = .01; χ 2 = 6.78, P = .01; χ 2 =3.99, P = .05, respectively), but were not found in patients whose conditions were diagnosed later in life. Men were significantly younger at diagnosis than were women. No obvious relation was found between HLA antigens and other clinical data. CONCLUSION: HLA-A26, B40, and DR9, which were found relatively frequently in the ancient Japanese population, seem to be associated with keratoconus in younger individuals.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(01)01368-X