Beta-blockers, exercise, and the immune system in men with coronary artery disease

The purpose of the present study was to examine the effect of aerobic exercise training on the immune system in coronary artery disease patients treated with beta-blockers. Twenty-five patients (46.1 +/- 2 yr) treated with atenolol, a beta-blocker agent, for 3 months before exercising were divided r...

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Bibliographic Details
Published in:Medicine and science in sports and exercise 2002-04, Vol.34 (4), p.587-591
Main Authors: SAGIV, Michael, BEN-SIRA, David, GOLDHAMMER, Ehud
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Adult
Atenolol - therapeutic use
Biological and medical sciences
Cardiology. Vascular system
CD4-CD8 Ratio
Coronary Artery Disease - drug therapy
Coronary Artery Disease - immunology
Coronary Artery Disease - physiopathology
Coronary heart disease
Exercise - physiology
Heart
Humans
Male
Medical sciences
Middle Aged
Space life sciences
T-Lymphocytes - immunology
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Summary:The purpose of the present study was to examine the effect of aerobic exercise training on the immune system in coronary artery disease patients treated with beta-blockers. Twenty-five patients (46.1 +/- 2 yr) treated with atenolol, a beta-blocker agent, for 3 months before exercising were divided randomly into two groups: 15 underwent an aerobic exercise training program for 12 wk at 65-70% of their work capacity, whereas the other 10 patients served as controls. After training, levels of CD4 and CD8 cells were significantly (P < 0.05) higher and concomitantly the CD4/CD8 ratio decreased significantly (P < 0.05) in the exercising group compared with the control group. Data suggest that coronary artery disease patients exercising aerobically at 65-70% of their work capacity gain a statistically significant higher lymphocyte T cell function as compared with their untrained counterparts.
ISSN:0195-9131
1530-0315
DOI:10.1097/00005768-200204000-00004