Acute posterior multifocal placoid pigment epitheliopathy and scleritis in a patient with pANCA-positive systemic vasculitis

PURPOSE: To present acute posterior multifocal placoid pigment epitheliopathy and scleritis occurring in association with pANCA (perinuclear antineutrophil cytoplasmic antibody)-positive systemic vasculitis. DESIGN: Interventional case report. METHODS: A 69-year-old woman developed bilateral acute p...

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Bibliographic Details
Published in:American journal of ophthalmology 2002-04, Vol.133 (4), p.566-568
Main Authors: Matsuo, Toshihiko, Horikoshi, Toshiko, Nagai, Chieko
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Antibodies, Antineutrophil Cytoplasmic - immunology
Biological and medical sciences
Bronchial Diseases - etiology
Diseases of cornea, anterior segment and sclera
Electrodiagnosis. Electric activity recording
Electrooculography. Electroretinography
Female
Glomerulonephritis - etiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Ophthalmology
Pigment Epithelium of Eye - pathology
Retinal Diseases - diagnosis
Retinal Diseases - etiology
Scleritis - diagnosis
Scleritis - etiology
Stomach Ulcer - etiology
Vasculitis - complications
Vasculitis - immunology
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Summary:PURPOSE: To present acute posterior multifocal placoid pigment epitheliopathy and scleritis occurring in association with pANCA (perinuclear antineutrophil cytoplasmic antibody)-positive systemic vasculitis. DESIGN: Interventional case report. METHODS: A 69-year-old woman developed bilateral acute posterior multifocal placoid pigment epitheliopathy concurrent with rapidly progressive glomerulonephritis and bronchioalveolitis in both lungs. RESULTS: The patient showed a high titer of pANCA (myeloperoxidase-ANCA). She then developed scleritis in the left eye and multiple gastric ulcers. CONCLUSION: Acute posterior multifocal placoid pigment epitheliopathy and scleritis in this patient are manifestations that are part of pANCA-positive systemic vasculitis. This association further supports that acute posterior multifocal placoid pigment epitheliopathy is caused by vasculitic inflammation of the choriocapillaris.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(01)01369-1