Impact of clinical and histopathological factors on outcome of Egyptian patients with crescentic glomerulonephritis

This study included 128 patients with crescentic glomerulonephritis (CGN) having sufficient clinical and histopathological data and were followed up in our institute for a mean period of 34 +/- 28 months. There were 49 males and 79 females with mean age 22.7 +/- 14 years. We studied the effect of cl...

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Bibliographic Details
Published in:International urology and nephrology 2003, Vol.35 (4), p.543-551
Main Authors: El-Husseini, A A, El-Agroudy, A E, Moustafa, F E, Fouda, M A, Sobh, M A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Egypt
Female
Glomerulonephritis - pathology
Glomerulonephritis - physiopathology
Humans
Male
Retrospective Studies
Survival Analysis
Treatment Outcome
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Summary:This study included 128 patients with crescentic glomerulonephritis (CGN) having sufficient clinical and histopathological data and were followed up in our institute for a mean period of 34 +/- 28 months. There were 49 males and 79 females with mean age 22.7 +/- 14 years. We studied the effect of clinical, laboratory and histopathological parameters on kidney function and patient survival at the end point of the study. The multivariate analysis revealed that serum creatinine at presentation, nephrotic range proteinuria during the follow up period, percentage of glomeruli affected by crescents, percentage of fibrous crescents and absence of cellular infiltration were significant risk factors affecting the kidney function at termination of the study. The only risk factor which correlated significantly with the patient mortality was the serum creatinine at last follows up.
ISSN:0301-1623
1573-2584
DOI:10.1023/B:UROL.0000025607.41722.aa