Proton MR spectroscopic imaging in multiple sclerosis

We studied 24 patients with multiple sclerosis (MS) by proton magnetic resonance spectroscopic imaging (1H-MRSI) to assess the neurochemical pathology of the white-matter lesions (WML) and normal-appearing white matter (NAWM). Our 1H-MRSI technique allowed simultaneous measurement of N-acetylasparta...

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Bibliographic Details
Published in:Neuroradiology 2002, Vol.44 (1), p.37-42
Main Authors: TEDESCHI, G, BONAVITA, S, MCFARLAND, H. F, RICHERT, N, DUYN, J. H, FRANK, J. A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Humans
Magnetic Resonance Spectroscopy
Male
Medical sciences
Middle Aged
Multiple Sclerosis - diagnosis
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
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Summary:We studied 24 patients with multiple sclerosis (MS) by proton magnetic resonance spectroscopic imaging (1H-MRSI) to assess the neurochemical pathology of the white-matter lesions (WML) and normal-appearing white matter (NAWM). Our 1H-MRSI technique allowed simultaneous measurement of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr) signal intensities from four 15-mm slices divided into 0.84 ml single-volume elements. In WML we found significantly lower NAA/Cr and NAA/Cho ratios and a significantly higher Cho/Cr ratio than in NAWM or control white matter. In NAWM, NAA/Cr and Cho/Cr were significantly lower than in control white matter. 1H-MRSI was compatible with damage to myelin in WML, and with axonal damage and/or dysfunction in WML and NAWM. These findings extend data on involvement of NAWM in MS beyond the abnormalities visible on MRI.
ISSN:0028-3940
1432-1920
DOI:10.1007/s002340100584