Magnetic resonance imaging study of the swelling kinetics of hydroxypropylmethylcellulose (HPMC) in water

Magnetic resonance imaging has been used to monitor the hydration of hydroxypropylmethylcellulose samples by two-dimensional mapping of properties such as spin density and relaxation times. The measurements were performed at two pH values of water: 2 and 6 and two temperatures 25 and 37°C. It is sho...

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Bibliographic Details
Published in:Journal of controlled release 2002-04, Vol.80 (1-3), p.79-86
Main Authors: TRITT-GOC, Jadwiga, PISLEWSKI, Narcyz
Format: Article
Language:English
Subjects:
Biological and medical sciences
Case II diffusion
Diffusion
Effective spin–spin map
Fickian diffusion
General pharmacology
Hemostatics - chemistry
Hemostatics - pharmacokinetics
Hydroxypropylmethylcellulose
Hypromellose Derivatives
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - statistics & numerical data
Medical sciences
Methylcellulose - analogs & derivatives
Methylcellulose - chemistry
Methylcellulose - pharmacokinetics
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Proton density map
Solvents - chemistry
Solvents - pharmacokinetics
Swelling
Water - chemistry
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Summary:Magnetic resonance imaging has been used to monitor the hydration of hydroxypropylmethylcellulose samples by two-dimensional mapping of properties such as spin density and relaxation times. The measurements were performed at two pH values of water: 2 and 6 and two temperatures 25 and 37°C. It is shown that transport behavior of water into HPMC changes from being almost completely relaxation controlled (case II) at pH=2 to Fickian behavior for pH=6. It was also observed that radial swelling is larger for the system composed of HPMC and water at pH=6 than at pH=2.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(01)00556-9