Accuracy and precision of intraocular injection volume

PURPOSE: To assess the accuracy and precision of methods in clinical use for intraocular drug injection. DESIGN: Experimental laboratory investigation. METHODS: A total of 800 injections were performed using 20 different 1-ml syringes at intended volumes of 0.10 ml and 0.05 ml. The volume of each in...

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Bibliographic Details
Published in:American journal of ophthalmology 2002-04, Vol.133 (4), p.564-566
Main Authors: Raju, Jhansi R., Weinberg, David V.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Eye
Injections - standards
Medical sciences
Ophthalmology - standards
Pharmacology. Drug treatments
Reference Standards
Reproducibility of Results
Syringes - standards
Weights and Measures - standards
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Summary:PURPOSE: To assess the accuracy and precision of methods in clinical use for intraocular drug injection. DESIGN: Experimental laboratory investigation. METHODS: A total of 800 injections were performed using 20 different 1-ml syringes at intended volumes of 0.10 ml and 0.05 ml. The volume of each injection was calculated from mass of water delivered onto an analytic balance. RESULTS: The mean measured volume delivered was less than the intended volume for every syringe ( P < .001 for each syringe at each volume). A total of 7% and 22% of injections differed by 20% or more from the intended volumes of 0.10 ml and 0.05 ml, respectively. Overdelivery of volume was uncommon. CONCLUSION: Clinically relevant materials and methods used for intraocular injection of drugs systematically underdelivered the intended volume.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(01)01408-8