Cutting edge: anti-inflammatory properties of low levels of IFN-gamma

Activation of naive T and B cells occurs only within the context of organized lymphoid tissue. Thus, the continuous recirculation of mature lymphocytes is crucial for the development of primary immune response to foreign Ags. We have previously shown that low levels of IFN-gamma inhibit homing of B...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2002-04, Vol.168 (8), p.3707-3711
Main Authors: Flaishon, Liat, Topilski, Ian, Shoseyov, David, Hershkoviz, Rami, Fireman, Elizabeth, Levo, Yoram, Marmor, Sylvia, Shachar, Idit
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Bronchial Hyperreactivity - immunology
Bronchial Hyperreactivity - pathology
Bronchial Hyperreactivity - prevention & control
Cell Adhesion - immunology
Cell Migration Inhibition
Cell Movement - immunology
Disease Models, Animal
Dose-Response Relationship, Immunologic
Down-Regulation - immunology
Drug Administration Schedule
Injections, Intraperitoneal
Integrins - antagonists & inhibitors
Integrins - physiology
Interferon-gamma - administration & dosage
Interferon-gamma - physiology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - pathology
T-Lymphocyte Subsets - physiology
Th2 Cells - immunology
Th2 Cells - metabolism
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Summary:Activation of naive T and B cells occurs only within the context of organized lymphoid tissue. Thus, the continuous recirculation of mature lymphocytes is crucial for the development of primary immune response to foreign Ags. We have previously shown that low levels of IFN-gamma inhibit homing of B cells to the secondary lymphoid organs. In this study, we demonstrate that similarly low doses of IFN-gamma down-regulate integrin-mediated adhesion and migration of naive T and Th2 cells, and have a profound effect on the in vivo homing of naive T cells to the lymph nodes. Moreover, we show that these low doses of IFN-gamma have anti-inflammatory effects in an in vivo asthma model. Thus, in contrast to the proinflammatory effects of IFN-gamma at relatively high concentrations, low dose IFN-gamma appears to exert global suppressory effects on T cell trafficking and may have clinical application as an anti-inflammatory agent.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.168.8.3707