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Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)
The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2' position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure-activity relationships explored.
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| Published in: | Bioorganic & medicinal chemistry letters 2002-04, Vol.12 (8), p.1185-1187 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c335t-76a7ebb8061c21b159dd104f3f2056b6048a381bae580c575d1e10d32eb34e203 |
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| cites | cdi_FETCH-LOGICAL-c335t-76a7ebb8061c21b159dd104f3f2056b6048a381bae580c575d1e10d32eb34e203 |
| container_end_page | 1187 |
| container_issue | 8 |
| container_start_page | 1185 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 12 |
| creator | SHAM, Hing L BETEBENNER, David A XIAOQI CHEN SALDIVAR, Ayda VASAVANONDA, Sudthida KEMPF, Dale J PLATTNER, Jacob J NORBECK, Daniel W |
| description | The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2' position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure-activity relationships explored. |
| doi_str_mv | 10.1016/S0960-894X(02)00134-8 |
| format | article |
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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>HIV Protease Inhibitors - chemical synthesis</topic><topic>HIV Protease Inhibitors - chemistry</topic><topic>HIV Protease Inhibitors - pharmacology</topic><topic>Humans</topic><topic>Lopinavir</topic><topic>Medical sciences</topic><topic>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2002-04, Vol.12 (8), p.1185-1187 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71586616 |
| source | ScienceDirect Freedom Collection |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cell Line HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology Humans Lopinavir Medical sciences Pharmacology. Drug treatments Pyrimidinones - chemical synthesis Pyrimidinones - chemistry Pyrimidinones - pharmacology Structure-Activity Relationship |
| title | Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir) |
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