Novel potent antagonists of human neuropeptide Y Y5 receptor. Part 1: 2-Oxobenzothiazolin-3-acetic acid derivatives

Novel NPY-Y5 antagonist FR73966 was discovered by screening of our in-house chemical library. The analogues were prepared by application of parallel synthesis techniques. Some of the resulting 2-oxobenzothiazolin-3-acetic acid derivatives exhibited nanomolar binding affinity for human NPY-Y5 recepto...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2002-04, Vol.12 (8), p.1171-1175
Main Authors: TABUCHI, Seiichiro, ITANI, Hiromichi, SAKATA, Yoshihiko, OOHASHI, Hiroko, SATOH, Yoshinari
Format: Article
Language:English
Subjects:
Biological and medical sciences
Humans
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Receptors, Neuropeptide Y - antagonists & inhibitors
Thiazoles - chemistry
Thiazoles - pharmacology
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Summary:Novel NPY-Y5 antagonist FR73966 was discovered by screening of our in-house chemical library. The analogues were prepared by application of parallel synthesis techniques. Some of the resulting 2-oxobenzothiazolin-3-acetic acid derivatives exhibited nanomolar binding affinity for human NPY-Y5 receptors.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(02)00113-0