Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)- N-phenylacetamide—a potential antileishmanial agent

Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)- N-phenylacetamide ( 2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the sp...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2002-06, Vol.10 (6), p.1687-1693
Main Authors: Sahu, Niranjan P., Pal, Chiranjib, Mandal, Nirup B., Banerjee, Sukdeb, Raha, Mausumi, Kundu, Ashis P., Basu, Anirban, Ghosh, Monidipa, Roy, Keshab, Bandyopadhyay, Santu
Format: Article
Language:English
Subjects:
Acetamides - chemical synthesis
Acetamides - pharmacology
Acetamides - therapeutic use
Acetanilides
Aminoquinolines - chemical synthesis
Aminoquinolines - pharmacology
Aminoquinolines - therapeutic use
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiprotozoal Agents - chemical synthesis
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Biological and medical sciences
Cell Cycle - drug effects
Cricetinae
Leishmania donovani - cytology
Leishmania donovani - drug effects
Leishmania donovani - growth & development
Leishmaniasis - blood
Leishmaniasis - drug therapy
Leishmaniasis - enzymology
Leishmaniasis - parasitology
Liver - drug effects
Liver - parasitology
Medical sciences
Mesocricetus
Molecular Structure
Pharmacology. Drug treatments
Spleen - drug effects
Spleen - parasitology
Time Factors
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Summary:Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)- N-phenylacetamide ( 2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug. Some novel quinoline derivatives were prepared and tested for antileishmanial activity in hamster models. 2-(2-Methylquinolin-4-ylamino)- N-phenylacetamide ( 2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load, both in the spleen and liver, at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(02)00046-9