Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease

An enhanced proteolysis of lung interstitium is key event in the pathogenesis of emphysema, a major constituent of chronic obstructive pulmonary disease. To assess whether urinary desmosine and/or hydroxyproline may be used as a marker of lung destruction we studied urinary excretions of these produ...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2002-06, Vol.34 (6), p.594-604
Main Authors: Cocci, Franca, Miniati, Massimo, Monti, Simonetta, Cavarra, Eleonora, Gambelli, Federica, Battolla, Luigi, Lucattelli, Monica, Lungarella, Giuseppe
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - urine
Cohort Studies
COPD
Desmosine - urine
Emphysema
Emphysema - urine
Enzyme-Linked Immunosorbent Assay
Female
HRCT
Humans
Hydroxyproline - urine
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive - urine
Reproducibility of Results
Respiratory Function Tests
Smoking - metabolism
Tomography, X-Ray Computed
Urinary desmosine
Urinary hydroxyproline
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Summary:An enhanced proteolysis of lung interstitium is key event in the pathogenesis of emphysema, a major constituent of chronic obstructive pulmonary disease. To assess whether urinary desmosine and/or hydroxyproline may be used as a marker of lung destruction we studied urinary excretions of these products in 20 patients with chronic obstructive pulmonary disease and in 19 appropriate controls in 24 h urine collection samples. For desmosine measurements, we developed a new indirect competitive enzyme-linked immunosorbent assay. The extent of emphysema was measured in high resolution computed tomography (CT) scans, by considering lung area with CT numbers
ISSN:1357-2725
1878-5875
DOI:10.1016/S1357-2725(02)00015-8