Loading…
Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats
During normal pregnancy, a gradual plasma volume expansion (VE) occurs and reaches a maximum level at late term. Pressure natriuresis and renal interstitial hydrostatic pressure (RIHP) responses are attenuated in pregnant rats. Also, basal RIHP is lower in pregnant rats, suggesting an increase in re...
Saved in:
Published in: | American journal of physiology. Renal physiology 2002-05, Vol.282 (5), p.F821-F825 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c391t-8e8e5812605aa3a2ffc699782a2f37fd3505d14237abca184c5e3272dc5d147f3 |
---|---|
cites | cdi_FETCH-LOGICAL-c391t-8e8e5812605aa3a2ffc699782a2f37fd3505d14237abca184c5e3272dc5d147f3 |
container_end_page | F825 |
container_issue | 5 |
container_start_page | F821 |
container_title | American journal of physiology. Renal physiology |
container_volume | 282 |
creator | Khraibi, Ali A Solhaug, Michael J Dobrian, Anca D Berndt, Theresa J |
description | During normal pregnancy, a gradual plasma volume expansion (VE) occurs and reaches a maximum level at late term. Pressure natriuresis and renal interstitial hydrostatic pressure (RIHP) responses are attenuated in pregnant rats. Also, basal RIHP is lower in pregnant rats, suggesting an increase in renal interstitial compliance during pregnancy. This adaptation may contribute to the increase in plasma volume that is required for a normal pregnancy, because increases in RIHP have been consistently shown to produce natriuresis and diuresis. Acute saline VE (5% body wt/30 min) has been shown to increase RIHP in normal nonpregnant rats. Therefore, the objective of this study was to determine RIHP, natriuretic, and diuretic responses to VE in nonpregnant (n = 7), midterm pregnant (n = 8), and late-term pregnant (n = 8) Sprague-Dawley rats. Although VE significantly increased RIHP, fractional excretion of sodium (FE(Na)), and urine flow rate (V) in all groups, DeltaRIHP was highest for nonpregnant (3.0 +/- 0.3 mmHg) compared with midterm pregnant (1.6 +/- 0.1 mmHg; P < 0.05 vs. nonpregnant) and late-term pregnant rats (1.2 +/- 0.1 mmHg; P < 0.05 vs. both midterm pregnant and nonpregnant rats). DeltaFE(Na) and DeltaV were similar in all groups: 5.8 +/- 1.0% and 231 +/- 27 microl/min for nonpregnant, 6.8 +/- 1.3% and 173 +/- 16 microl/min for midterm pregnant, and 7.6 +/- 1.2% and 203 +/- 10 microl/min for late-term pregnant rats, respectively. In conclusion, basal RIHP and the increase in RIHP during VE were attenuated during pregnancy; however, the natriuretic and diuretic responses to VE remain intact during the course of pregnancy. |
doi_str_mv | 10.1152/ajprenal.00254.2001 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71591970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71591970</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-8e8e5812605aa3a2ffc699782a2f37fd3505d14237abca184c5e3272dc5d147f3</originalsourceid><addsrcrecordid>eNpFUFtLwzAUDqK4Of0FguTJt86cpGnaRxneQBBEwbeQpalmtGlNUnH_3tRNfDqX73I4H0LnQJYAnF6pzeCNU-2SEMrzJSUEDtA8ITSDvCgOU18xyEou3mboJIQNSQygcIxmkJC8qGCOmufJAlsXjQ_RRpuGj23t-xBVtBqnEyGM3mDlauxU9DYNE5D2Q--CCTj2-Ktvx85g8z0oF2zvkt-kfHfKRexVDKfoqFFtMGf7ukCvtzcvq_vs8enuYXX9mGlWQcxKUxpeAi0IV4op2jS6qCpR0tQy0dSME15DTplQa62gzDU3jApa62ktGrZAlzvfwfefowlRdjZo07bKmX4MUgCvoBIkEdmOqNOrwZtGDt52ym8lEDnFK__ilb_xyinepLrY24_rztT_mn2e7AfBxXr6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71591970</pqid></control><display><type>article</type><title>Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats</title><source>American Physiological Society Free</source><creator>Khraibi, Ali A ; Solhaug, Michael J ; Dobrian, Anca D ; Berndt, Theresa J</creator><creatorcontrib>Khraibi, Ali A ; Solhaug, Michael J ; Dobrian, Anca D ; Berndt, Theresa J</creatorcontrib><description>During normal pregnancy, a gradual plasma volume expansion (VE) occurs and reaches a maximum level at late term. Pressure natriuresis and renal interstitial hydrostatic pressure (RIHP) responses are attenuated in pregnant rats. Also, basal RIHP is lower in pregnant rats, suggesting an increase in renal interstitial compliance during pregnancy. This adaptation may contribute to the increase in plasma volume that is required for a normal pregnancy, because increases in RIHP have been consistently shown to produce natriuresis and diuresis. Acute saline VE (5% body wt/30 min) has been shown to increase RIHP in normal nonpregnant rats. Therefore, the objective of this study was to determine RIHP, natriuretic, and diuretic responses to VE in nonpregnant (n = 7), midterm pregnant (n = 8), and late-term pregnant (n = 8) Sprague-Dawley rats. Although VE significantly increased RIHP, fractional excretion of sodium (FE(Na)), and urine flow rate (V) in all groups, DeltaRIHP was highest for nonpregnant (3.0 +/- 0.3 mmHg) compared with midterm pregnant (1.6 +/- 0.1 mmHg; P < 0.05 vs. nonpregnant) and late-term pregnant rats (1.2 +/- 0.1 mmHg; P < 0.05 vs. both midterm pregnant and nonpregnant rats). DeltaFE(Na) and DeltaV were similar in all groups: 5.8 +/- 1.0% and 231 +/- 27 microl/min for nonpregnant, 6.8 +/- 1.3% and 173 +/- 16 microl/min for midterm pregnant, and 7.6 +/- 1.2% and 203 +/- 10 microl/min for late-term pregnant rats, respectively. In conclusion, basal RIHP and the increase in RIHP during VE were attenuated during pregnancy; however, the natriuretic and diuretic responses to VE remain intact during the course of pregnancy.</description><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 1522-1466</identifier><identifier>DOI: 10.1152/ajprenal.00254.2001</identifier><identifier>PMID: 11934691</identifier><language>eng</language><publisher>United States</publisher><subject>Absorption ; Animals ; Diuresis ; Extracellular Space - physiology ; Female ; Gestational Age ; Hydrostatic Pressure ; Kidney - physiology ; Kidney Tubules, Proximal - physiology ; Natriuresis ; Plasma Volume - physiology ; Pregnancy ; Pregnancy, Animal - physiology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>American journal of physiology. Renal physiology, 2002-05, Vol.282 (5), p.F821-F825</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-8e8e5812605aa3a2ffc699782a2f37fd3505d14237abca184c5e3272dc5d147f3</citedby><cites>FETCH-LOGICAL-c391t-8e8e5812605aa3a2ffc699782a2f37fd3505d14237abca184c5e3272dc5d147f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11934691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khraibi, Ali A</creatorcontrib><creatorcontrib>Solhaug, Michael J</creatorcontrib><creatorcontrib>Dobrian, Anca D</creatorcontrib><creatorcontrib>Berndt, Theresa J</creatorcontrib><title>Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats</title><title>American journal of physiology. Renal physiology</title><addtitle>Am J Physiol Renal Physiol</addtitle><description>During normal pregnancy, a gradual plasma volume expansion (VE) occurs and reaches a maximum level at late term. Pressure natriuresis and renal interstitial hydrostatic pressure (RIHP) responses are attenuated in pregnant rats. Also, basal RIHP is lower in pregnant rats, suggesting an increase in renal interstitial compliance during pregnancy. This adaptation may contribute to the increase in plasma volume that is required for a normal pregnancy, because increases in RIHP have been consistently shown to produce natriuresis and diuresis. Acute saline VE (5% body wt/30 min) has been shown to increase RIHP in normal nonpregnant rats. Therefore, the objective of this study was to determine RIHP, natriuretic, and diuretic responses to VE in nonpregnant (n = 7), midterm pregnant (n = 8), and late-term pregnant (n = 8) Sprague-Dawley rats. Although VE significantly increased RIHP, fractional excretion of sodium (FE(Na)), and urine flow rate (V) in all groups, DeltaRIHP was highest for nonpregnant (3.0 +/- 0.3 mmHg) compared with midterm pregnant (1.6 +/- 0.1 mmHg; P < 0.05 vs. nonpregnant) and late-term pregnant rats (1.2 +/- 0.1 mmHg; P < 0.05 vs. both midterm pregnant and nonpregnant rats). DeltaFE(Na) and DeltaV were similar in all groups: 5.8 +/- 1.0% and 231 +/- 27 microl/min for nonpregnant, 6.8 +/- 1.3% and 173 +/- 16 microl/min for midterm pregnant, and 7.6 +/- 1.2% and 203 +/- 10 microl/min for late-term pregnant rats, respectively. In conclusion, basal RIHP and the increase in RIHP during VE were attenuated during pregnancy; however, the natriuretic and diuretic responses to VE remain intact during the course of pregnancy.</description><subject>Absorption</subject><subject>Animals</subject><subject>Diuresis</subject><subject>Extracellular Space - physiology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Hydrostatic Pressure</subject><subject>Kidney - physiology</subject><subject>Kidney Tubules, Proximal - physiology</subject><subject>Natriuresis</subject><subject>Plasma Volume - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1931-857X</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpFUFtLwzAUDqK4Of0FguTJt86cpGnaRxneQBBEwbeQpalmtGlNUnH_3tRNfDqX73I4H0LnQJYAnF6pzeCNU-2SEMrzJSUEDtA8ITSDvCgOU18xyEou3mboJIQNSQygcIxmkJC8qGCOmufJAlsXjQ_RRpuGj23t-xBVtBqnEyGM3mDlauxU9DYNE5D2Q--CCTj2-Ktvx85g8z0oF2zvkt-kfHfKRexVDKfoqFFtMGf7ukCvtzcvq_vs8enuYXX9mGlWQcxKUxpeAi0IV4op2jS6qCpR0tQy0dSME15DTplQa62gzDU3jApa62ktGrZAlzvfwfefowlRdjZo07bKmX4MUgCvoBIkEdmOqNOrwZtGDt52ym8lEDnFK__ilb_xyinepLrY24_rztT_mn2e7AfBxXr6</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Khraibi, Ali A</creator><creator>Solhaug, Michael J</creator><creator>Dobrian, Anca D</creator><creator>Berndt, Theresa J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats</title><author>Khraibi, Ali A ; Solhaug, Michael J ; Dobrian, Anca D ; Berndt, Theresa J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-8e8e5812605aa3a2ffc699782a2f37fd3505d14237abca184c5e3272dc5d147f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Diuresis</topic><topic>Extracellular Space - physiology</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Hydrostatic Pressure</topic><topic>Kidney - physiology</topic><topic>Kidney Tubules, Proximal - physiology</topic><topic>Natriuresis</topic><topic>Plasma Volume - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khraibi, Ali A</creatorcontrib><creatorcontrib>Solhaug, Michael J</creatorcontrib><creatorcontrib>Dobrian, Anca D</creatorcontrib><creatorcontrib>Berndt, Theresa J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Renal physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khraibi, Ali A</au><au>Solhaug, Michael J</au><au>Dobrian, Anca D</au><au>Berndt, Theresa J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats</atitle><jtitle>American journal of physiology. Renal physiology</jtitle><addtitle>Am J Physiol Renal Physiol</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>282</volume><issue>5</issue><spage>F821</spage><epage>F825</epage><pages>F821-F825</pages><issn>1931-857X</issn><eissn>1522-1466</eissn><abstract>During normal pregnancy, a gradual plasma volume expansion (VE) occurs and reaches a maximum level at late term. Pressure natriuresis and renal interstitial hydrostatic pressure (RIHP) responses are attenuated in pregnant rats. Also, basal RIHP is lower in pregnant rats, suggesting an increase in renal interstitial compliance during pregnancy. This adaptation may contribute to the increase in plasma volume that is required for a normal pregnancy, because increases in RIHP have been consistently shown to produce natriuresis and diuresis. Acute saline VE (5% body wt/30 min) has been shown to increase RIHP in normal nonpregnant rats. Therefore, the objective of this study was to determine RIHP, natriuretic, and diuretic responses to VE in nonpregnant (n = 7), midterm pregnant (n = 8), and late-term pregnant (n = 8) Sprague-Dawley rats. Although VE significantly increased RIHP, fractional excretion of sodium (FE(Na)), and urine flow rate (V) in all groups, DeltaRIHP was highest for nonpregnant (3.0 +/- 0.3 mmHg) compared with midterm pregnant (1.6 +/- 0.1 mmHg; P < 0.05 vs. nonpregnant) and late-term pregnant rats (1.2 +/- 0.1 mmHg; P < 0.05 vs. both midterm pregnant and nonpregnant rats). DeltaFE(Na) and DeltaV were similar in all groups: 5.8 +/- 1.0% and 231 +/- 27 microl/min for nonpregnant, 6.8 +/- 1.3% and 173 +/- 16 microl/min for midterm pregnant, and 7.6 +/- 1.2% and 203 +/- 10 microl/min for late-term pregnant rats, respectively. In conclusion, basal RIHP and the increase in RIHP during VE were attenuated during pregnancy; however, the natriuretic and diuretic responses to VE remain intact during the course of pregnancy.</abstract><cop>United States</cop><pmid>11934691</pmid><doi>10.1152/ajprenal.00254.2001</doi></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1931-857X |
ispartof | American journal of physiology. Renal physiology, 2002-05, Vol.282 (5), p.F821-F825 |
issn | 1931-857X 1522-1466 |
language | eng |
recordid | cdi_proquest_miscellaneous_71591970 |
source | American Physiological Society Free |
subjects | Absorption Animals Diuresis Extracellular Space - physiology Female Gestational Age Hydrostatic Pressure Kidney - physiology Kidney Tubules, Proximal - physiology Natriuresis Plasma Volume - physiology Pregnancy Pregnancy, Animal - physiology Rats Rats, Sprague-Dawley |
title | Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T22%3A25%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Renal%20interstitial%20hydrostatic%20pressure%20and%20natriuretic%20responses%20to%20volume%20expansion%20in%20pregnant%20rats&rft.jtitle=American%20journal%20of%20physiology.%20Renal%20physiology&rft.au=Khraibi,%20Ali%20A&rft.date=2002-05-01&rft.volume=282&rft.issue=5&rft.spage=F821&rft.epage=F825&rft.pages=F821-F825&rft.issn=1931-857X&rft.eissn=1522-1466&rft_id=info:doi/10.1152/ajprenal.00254.2001&rft_dat=%3Cproquest_cross%3E71591970%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c391t-8e8e5812605aa3a2ffc699782a2f37fd3505d14237abca184c5e3272dc5d147f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=71591970&rft_id=info:pmid/11934691&rfr_iscdi=true |