Megakaryocytopoiesis under hypoxic conditions

Acute and chronic hypoxia led to acceleration of proliferation and differentiation of bone marrow megakaryocytes and increase in their functional activity. The count of young cells in the peripheral blood increased during acute hypoxia. Chronic hypoxia led to increase in the number of old platelets...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-12, Vol.136 (6), p.554-556
Main Authors: Lebedeva, E V, Yushkov, B G, Chereshnev, V A
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - pharmacology
Animals
Animals, Outbred Strains
Blood Platelets - cytology
Bone Marrow Cells - cytology
Cell Differentiation
Cell Division
Cell Size
Epinephrine - pharmacology
Femur - cytology
Hypoxia - blood
Hypoxia - pathology
Male
Megakaryocytes - cytology
Megakaryocytes - metabolism
Platelet Adhesiveness
Platelet Aggregation - drug effects
Platelet Count
Rats
Thrombocytosis - etiology
Thrombopoiesis
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Summary:Acute and chronic hypoxia led to acceleration of proliferation and differentiation of bone marrow megakaryocytes and increase in their functional activity. The count of young cells in the peripheral blood increased during acute hypoxia. Chronic hypoxia led to increase in the number of old platelets with lower functional activity, which was accompanied by thrombocytosis.
ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000020201.51742.28