Dietary Restriction in Long-Lived Dwarf Flies

Using the fruit fly Drosophila, Clancy et al show that slowing of aging by a mutation in an insulin/insulin-like growth factor (IGF)-like signaling (IIS) pathway and by dietary restriction occurs by overlapping mechanisms and life-span must be maximized by at least one of the interventions under inv...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2002-04, Vol.296 (5566), p.319-319
Main Authors: Clancy, David J., Gems, David, Hafen, Ernst, Leevers, Sally J., Partridge, Linda
Format: Article
Language:English
Subjects:
Aging
Aging (Biology)
Animals
Biochemistry. Physiology. Immunology
Biological and medical sciences
Biology
Body Constitution
Brevia
Carrier Proteins
Diet
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Drosophila Proteins - genetics
Drosophila Proteins - physiology
Dwarfism
Energy Intake
Female
Female animals
Females
Food
Fundamental and applied biological sciences. Psychology
Genes, Insect
House mouse
Insecta
Insects
Insulin
Insulin Receptor Substrate Proteins
Intracellular Signaling Peptides and Proteins
Invertebrates
Longevity - physiology
Mice
Mice as laboratory animals
Mutation
Nutrition
Physiology. Development
Receptor, Insulin - physiology
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Summary:Using the fruit fly Drosophila, Clancy et al show that slowing of aging by a mutation in an insulin/insulin-like growth factor (IGF)-like signaling (IIS) pathway and by dietary restriction occurs by overlapping mechanisms and life-span must be maximized by at least one of the interventions under investigation for a proper test of the hypothesis that the mechanisms of life-span extension differ.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1069366