Dynamic cerebral autoregulation in healthy adolescents

Background: There is little information on the limits of cerebral autoregulation and the autoregulatory capacity in children. The aim of this study was to compare dynamic cerebral autoregulation between healthy adolescents and adults. Methods: Seventeen healthy volunteers 12–17 years (n = 8) and 25–...

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Published in:Acta anaesthesiologica Scandinavica 2002-04, Vol.46 (4), p.393-397
Main Authors: Vavilala, M. S., Newell, D. W., Junger, E., Douville, C. M., Aaslid, R., Rivara, F. P., Lam, A. M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aging - physiology
ARI
autoregulation
Biological and medical sciences
Blood Pressure - physiology
cerebral bloodflow
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Cerebrovascular Circulation - physiology
Child
children
dynamic autoregulation
Fundamental and applied biological sciences. Psychology
Heart Rate - physiology
Homeostasis - physiology
Humans
Middle Aged
Middle Cerebral Artery - physiology
Reference Values
Vertebrates: nervous system and sense organs
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Summary:Background: There is little information on the limits of cerebral autoregulation and the autoregulatory capacity in children. The aim of this study was to compare dynamic cerebral autoregulation between healthy adolescents and adults. Methods: Seventeen healthy volunteers 12–17 years (n = 8) and 25–45 years (n = 9) were enrolled in this study. Bilateral mean middle cerebral artery flow velocities (Vmca; (cm/s)) were measured using transcranial Doppler ultrasonography (TCD). Mean arterial blood pressure (MAP) and end‐tidal carbon dioxide were measured continuously during dynamic cerebral autoregulation studies. Blood pressure cuffs were placed around both thighs and inflated to 30 mmHg above the systolic blood pressure for 3 min and then rapidly deflated, resulting in transient systemic hypotension. The change of Vmca to change in MAP constitutes the autoregulatory response, and the speed of this response was quantified using computer model parameter estimation. The dynamic autoregulatory index (ARI) was averaged between the two sides. Results: Adolescents had significantly lower ARI (3.9 ± 2.1 vs. 5.3 ± 0.8; P=0.05), and higher Vmca (75.2 ± 15.2 vs. 57.6 ± 15.0; P
ISSN:0001-5172
1399-6576
DOI:10.1034/j.1399-6576.2002.460411.x