MRI of insulitis in autoimmune diabetes

Development of imaging techniques that would allow the mapping of immune cells in vivo could greatly aid our understanding of a number of inflammatory and autoimmune diseases. The current study focused on imaging of autoimmune destruction of the insulin‐producing pancreatic beta‐cells by cytotoxic l...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2002-04, Vol.47 (4), p.751-758
Main Authors: Moore, Anna, Zhe Sun, Phillip, Cory, David, Högemann, Dagmar, Weissleder, Ralph, Lipes, Myra A.
Format: Article
Language:English
Subjects:
Adoptive Transfer
Animals
Biological and medical sciences
contrast agents
Contrast Media
diabetes
Diabetes Mellitus, Type 1 - pathology
Gene Products, tat
inflammation
Investigative techniques, diagnostic techniques (general aspects)
Iron
Islets of Langerhans - immunology
Islets of Langerhans - pathology
lymphocyte
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, SCID
Microscopy, Fluorescence
Miscellaneous. Technology
MRI
Oxides
Radiodiagnosis. Nmr imagery. Nmr spectrometry
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Cytotoxic - pathology
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Summary:Development of imaging techniques that would allow the mapping of immune cells in vivo could greatly aid our understanding of a number of inflammatory and autoimmune diseases. The current study focused on imaging of autoimmune destruction of the insulin‐producing pancreatic beta‐cells by cytotoxic lymphocytes, the cause of insulin‐dependent diabetes mellitus (IDDM; Type 1 diabetes). Using high‐resolution MR microscopy and a conventional clinical MR imaging system, it was possible to visualize the infiltration of immune cells in the diabetic mouse pancreas. Mouse lymphocytes were visualized by magnetically labeling them with recently developed magnetic nanoparticles (CLIO‐Tat). The results from this study could potentially lead to detection of immune infiltration during diabetes formation in vivo, which would be one of the earliest parameters of disease development. Magn Reson Med 47:751–758, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.10110