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Dense innervation in pseudocapsular tissue compared to aneural interface tissue in loose totally replaced hips
BACKGROUND: The function of many inflammatory cells is in part regulated by neuronal cells, which may lead to so-called neurogenic inflammation. Sensory nerves also mediate the pain sensation. METHODS: This immunohistochemical study focused on visualization of C-sensory and sympathetic innervation i...
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Published in: | Journal of rheumatology 2002-04, Vol.29 (4), p.796-803 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | BACKGROUND: The function of many inflammatory cells is in part regulated by neuronal cells, which may lead to so-called neurogenic
inflammation. Sensory nerves also mediate the pain sensation. METHODS: This immunohistochemical study focused on visualization
of C-sensory and sympathetic innervation in the synovial membrane-like interface and pseudocapsular tissue around loosened
total hip replacement. RESULTS: The synovial membrane-like interface did not contain C-sensory peptidergic or sympathetic
neural structures. Only limited attempts to neural regeneration were detected. In contrast, pseudocapsule expressed dense
innervation with strong CPON-ir sympathetic innervation and osteoarthritis also had C-sensory fibers. Intense neural regeneration
was seen in these synovial membranes. Surprisingly, stellate and/or highly dendritic fibroblast-like cells in the fibrotic
areas in the interface tissue expressed strong immunoreactivity to the neural marker PGP 9.5, ubiquitin carboxyterminal hydrolase.
CONCLUSION: Pain related to aseptic loosening cannot arise in the aneural interface membrane. Inflammation in interface/aseptic
loosening seems to be driven by non-neurogenic factors, such as foreign bodies and micromovement. Insufficient lysosomal degradation
of denatured proteins causes accumulation of ubiquitinated conjugates and enzymes involved in the process. This leads to insufficient
degradation of platelet derived growth factor (PDGF)-receptor complex and can contribute to the accumulation of connective
tissue in the interface. Failure in ubiquitin mediated proteolysis might support overgrowth of interface tissue and aseptic
loosening. |
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ISSN: | 0315-162X 1499-2752 |