Benzo[alpyrene induction of cytochrome P450 1A1/1A2 in the lymph nodes of rats

Studies of mesenteric lymph nodes of rats by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A/1A2 after oral dose of benzo[a]pyrene showed the presence of these cytochrome forms in monocytes, macrophages, reticular and litoral cells, cell detritus, and liquid conten...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-12, Vol.136 (6), p.611-614
Main Authors: Borodin, Yu I, Safina, A F, Maiborodin, I V, Grishanova, A Yu
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - metabolism
Benzo(a)pyrene - metabolism
Cytochrome P-450 CYP1A1 - biosynthesis
Cytochrome P-450 CYP1A1 - metabolism
Cytochrome P-450 CYP1A2 - biosynthesis
Cytochrome P-450 CYP1A2 - metabolism
Enzyme Induction
Immunoenzyme Techniques
Isoenzymes - biosynthesis
Isoenzymes - metabolism
Lymph Nodes - enzymology
Macrophages, Peritoneal - enzymology
Male
Monocytes - enzymology
Rats
Rats, Wistar
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Summary:Studies of mesenteric lymph nodes of rats by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A/1A2 after oral dose of benzo[a]pyrene showed the presence of these cytochrome forms in monocytes, macrophages, reticular and litoral cells, cell detritus, and liquid contents of the paracortical zone and medullary substance sinuses. Oxidation of various exo- and endogenous toxins in the lymph nodes was revealed.
ISSN:0007-4888