Sequential MRI in a case of Creutzfeldt-Jakob disease

A 48-year-old man suddenly developed clinically and electroencephalographically nonspecific dementia. On MRI sequences, only diffusion-weighted images (DWI) of the cortex were unequivocally pathological. Obvious atrophy and basal ganglia signal changes appeared only 9 months after the onset. Brain b...

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Bibliographic Details
Published in:Neuroradiology 2002-03, Vol.44 (3), p.223-226
Main Authors: TRIBL, G. G, STRASSER, G, ZEITLHOFER, J, ASENBAUM, S, JARIUS, C, WESSELY, P, PRAYER, D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - pathology
Contrast Media
Creutzfeldt-Jakob Syndrome - diagnosis
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Electroencephalography
Gadolinium DTPA
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Medical sciences
Middle Aged
Neurology
Time Factors
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Description
Summary:A 48-year-old man suddenly developed clinically and electroencephalographically nonspecific dementia. On MRI sequences, only diffusion-weighted images (DWI) of the cortex were unequivocally pathological. Obvious atrophy and basal ganglia signal changes appeared only 9 months after the onset. Brain biopsy confirmed Creutzfeldt-Jakob disease (CJD). In rapidly progressive dementia, we recommend DWI for early diagnosis of CJD.
ISSN:0028-3940
1432-1920
DOI:10.1007/s002340100695