Analysis of key cell-cycle checkpoint proteins in colorectal tumours

Aberrations in the components of cell‐cycle checkpoints are a common feature of many tumours and several have been shown to have prognostic significance in colorectal cancer. In this study, seven components of cell‐cycle control [cyclin D1, retinoblastoma (pRb), p21, p27, p16, p53, and proliferating...

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Bibliographic Details
Published in:The Journal of pathology 2002-04, Vol.196 (4), p.386-393
Main Authors: McKay, Judith A., Douglas, Joy J., Ross, Val G., Curran, Stephanie, Loane, Joseph F., Ahmed, Fareeda Y., Cassidy, Jim, McLeod, Howard L., Murray, Graeme I.
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - metabolism
cell cycle
Cell Cycle Proteins - metabolism
checkpoints
colorectal cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
immunohistochemistry
Male
Medical sciences
Middle Aged
Neoplasm Proteins - metabolism
Prognosis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Tumors
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Summary:Aberrations in the components of cell‐cycle checkpoints are a common feature of many tumours and several have been shown to have prognostic significance in colorectal cancer. In this study, seven components of cell‐cycle control [cyclin D1, retinoblastoma (pRb), p21, p27, p16, p53, and proliferating cell nuclear antigen (PCNA)] were examined in a large series of well‐characterized colorectal adenocarcinomas using immunohistochemistry to ascertain co‐regulation and influence on survival. The majority (92%) of the tumours had abnormal staining of ⩾2 cell‐cycle control factors. Expression of cyclin D1 protein was correlated with both p21 (p
ISSN:0022-3417
1096-9896
DOI:10.1002/path.1053