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Treatment of Murine Cutaneous Melanoma with Near Infrared Light

Treatment of cutaneous melanoma (M-3 and B16-F10 implanted in mice) with rapidly-scanned, tightly-focused near infrared light elicits selective destruction of tumor tissue. A single laser treatment yielded complete eradication in >90% of B16-F10 tumors with thicknesses of approximately 3 mm; amel...

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Bibliographic Details
Published in:Photochemistry and photobiology 2002-03, Vol.75 (3), p.296-301
Main Authors: Dees, C., Harkins, J., Petersen, M. G., Fisher, W. G., Wachter, E. A.
Format: Article
Language:English
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Summary:Treatment of cutaneous melanoma (M-3 and B16-F10 implanted in mice) with rapidly-scanned, tightly-focused near infrared light elicits selective destruction of tumor tissue. A single laser treatment yielded complete eradication in >90% of B16-F10 tumors with thicknesses of approximately 3 mm; amelanotic M-3 tumors proved less responsive (ca 25% clearance rate). In addition to local tumor destruction, laser treatment of B16-F10 tumors in immunocompetent mice stimulated enhanced cytokine levels (interleukin-2 and interleukin-10) within treated tumor tissues and rejection of tumor cells upon a subsequent challenge dose. Such an antitumor immune response may lead to improved outcomes at both the treatment site and at sites of distant metastasis.
ISSN:0031-8655
1751-1097
DOI:10.1562/0031-8655(2002)075<0296:TOMCMW>2.0.CO;2