Cardiac arrest cerebral ischemia model in mice failed to cause delayed neuronal death in the hippocampus

Global cerebral ischemia models for genetically engineered mice are of particular importance for the study of delayed neuronal death, but have been complicated by variability of vascular anatomy. Here we developed a 5-min cardiac arrest model that was not affected by vascular anatomy, and evaluated...

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Bibliographic Details
Published in:Neuroscience letters 2002-04, Vol.322 (2), p.91-94
Main Authors: Kawahara, Nobutaka, Kawai, Kensuke, Toyoda, Tomikatsu, Nakatomi, Hirofumi, Furuya, Kazuhide, Kirino, Takaaki
Format: Article
Language:English
Subjects:
Animals
Anoxic depolarization
Biological and medical sciences
Brain Ischemia - pathology
Brain Ischemia - physiopathology
Cardiac arrest
Cell Death - physiology
Cerebral ischemia
Delayed neuronal death
Direct current potential
Disease Models, Animal
Heart Arrest - pathology
Heart Arrest - physiopathology
Hippocampus - cytology
Hippocampus - pathology
Hippocampus - physiopathology
Hypothermia
Male
Medical sciences
Mice
Mice, Inbred C57BL
Neurology
Neurons - cytology
Neurons - pathology
Vascular diseases and vascular malformations of the nervous system
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Summary:Global cerebral ischemia models for genetically engineered mice are of particular importance for the study of delayed neuronal death, but have been complicated by variability of vascular anatomy. Here we developed a 5-min cardiac arrest model that was not affected by vascular anatomy, and evaluated the hippocampal neuronal injury in BL/6 and SV129 mice. Despite prolonged anoxic depolarization for approximately 7 min, however, no consistent ischemic neuronal injury was noted in the CA1 sector of the hippocampus in both strains. Thus, our observations suggested that murine hippocampal neurons are relatively resistant to ischemia compared with those in other rodents.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)00101-5