Autologous thrombin for treatment of pseudoaneurysms

Femoral pseudoaneurysms arise in up to 2% of patients after femoral cannulation for cardiac catheterisation. We used autologous thrombin for percutaneous obliteration of pseudoaneurysms occurring after catheterisation. We prepared autologous thrombin isolates from blood of ten patients with femoral...

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Bibliographic Details
Published in:The Lancet (British edition) 2002-03, Vol.359 (9310), p.946-947
Main Authors: Quarmby, John W, Engelke, Christoph, Chitolie, Andrew, Morgan, Robert A, Belli, Anna-Maria
Format: Article
Language:English
Subjects:
Anaphylaxis
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Aneurysm, False - drug therapy
Aneurysms
Biological and medical sciences
Blood
Cannulation
Contamination
Emergency and intensive care: techniques, logistics
Female
Femoral Artery
Femur
Heart
Humans
Intensive care medicine
Male
Medical disorders
Medical research
Medical sciences
Middle Aged
Patients
Perfusions. Catheterizations. Hyperbaric oxygenotherapy
Prion protein
Prions
Surgery
Thrombin
Thrombin - isolation & purification
Thrombin - therapeutic use
Thromboembolism
Thrombosis
Treatment Outcome
Ultrasonic imaging
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Summary:Femoral pseudoaneurysms arise in up to 2% of patients after femoral cannulation for cardiac catheterisation. We used autologous thrombin for percutaneous obliteration of pseudoaneurysms occurring after catheterisation. We prepared autologous thrombin isolates from blood of ten patients with femoral pseudoaneurysms, and injected this solution into the pseudoaneurysms with duplex imaging guidance. We then assayed thrombin activity. All pseudoaneurysms were successfully thrombosed without substantial complications, although three patients needed a repeat procedure within 24 h. We have shown that autologous thrombin-induced thrombosis of pseudoaneurysms is reliable, simple, safe, and cheaper than commercial bovine or human thrombin, and avoids risks of anaphylaxis and contamination with prions.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(02)07991-6