Effects of Hyperinsulinaemia under Euglycaemic Condition on Liver Fat Metabolism in Dairy Cows in Early and Mid-lactation

The objective was to examine the effects of insulin under euglycaemic conditions on liver long chain fatty acids (LCFA) metabolism with special focus on the aetiology of hepatic lipidosis in early lactation. A 4‐day hyperinsulinaemic–euglycaemic clamp (clamp) was conducted on four dairy cows startin...

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Bibliographic Details
Published in:Journal of veterinary medicine. Series A 2002-03, Vol.49 (2), p.65-71
Main Authors: ANDERSEN, J. B., MASHEK, D. G., LARSEN, T., NIELSEN, M. O., INGVARTSEN, K. L.
Format: Article
Language:English
Subjects:
Animals
Cattle - blood
Cattle - physiology
Dairying
Fatty Acids, Nonesterified - metabolism
Female
Glucose Clamp Technique - veterinary
Insulin - administration & dosage
Insulin - blood
Insulin - pharmacology
Lactation - metabolism
Liver - drug effects
Liver - metabolism
Liver - pathology
Palmitates - metabolism
Pregnancy
Triglycerides - metabolism
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Summary:The objective was to examine the effects of insulin under euglycaemic conditions on liver long chain fatty acids (LCFA) metabolism with special focus on the aetiology of hepatic lipidosis in early lactation. A 4‐day hyperinsulinaemic–euglycaemic clamp (clamp) was conducted on four dairy cows starting in weeks 4 and 17 postpartum. Insulin was infused continuously (1 μg/kg BW per h) and a 50 % glucose solution was infused to maintain euglycaemia. Liver biopsies were taken 6 days before, the last day of, and 5 days after the clamp, and blood samples were taken in the same period. In the liver tissue, the relative triglyceride content decreased (P 
ISSN:0931-184X
1439-0442
DOI:10.1046/j.1439-0442.2002.jv417.x