Benzodiazepines inhibit the rate of neutrophil apoptosis

Benzodiazepines, which are commonly administered perioperatively, can depress immune function. Neutrophil apoptosis plays a central role in the regulation of inflammation. This is particularly important during and after surgery. To examine the effects of benzodiazepines (midazolam and diazepam) on n...

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Published in:Irish journal of medical science 2003-10, Vol.172 (4), p.191-194
Main Authors: Goto, Y, O'Malley, C, Fanning, N F, Wang, J, Redmond, H P, Shorten, G D
Format: Article
Language:English
Subjects:
Adult
Apoptosis - drug effects
Benzodiazepines - pharmacology
Cells, Cultured
Diazepam - pharmacology
Female
Humans
Male
Midazolam - pharmacology
Neutrophils - cytology
Neutrophils - drug effects
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Summary:Benzodiazepines, which are commonly administered perioperatively, can depress immune function. Neutrophil apoptosis plays a central role in the regulation of inflammation. This is particularly important during and after surgery. To examine the effects of benzodiazepines (midazolam and diazepam) on neutrophil apoptosis. Venous blood samples were withdrawn from patients scheduled to undergo elective surgery, (a) immediately prior to, and 10 minutes after administration of midazolam 0.2 mg/kg intravenously (n=11) and (b) immediately prior to, and 60 minutes after administration of diazepam 10 mg p.o. (n=10). Neutrophil apoptosis was measured by Annexin V-FITC after 1 and 12 hours in culture. The percentage of apoptotic cells was significantly less after midazolam at 12% (11.9) hours in culture compared to pre-midazolam 29.7% (13.3) (p
ISSN:0021-1265
1863-4362
DOI:10.1007/BF02915288