Genomic imprinting at the mammalian Dlk1-Dio3 domain

Genomic imprinting causes genes to be expressed or repressed depending on their parental origin. The majority of imprinted genes identified to date map in clusters and much of our knowledge of the mechanisms, function and evolution of imprinting have emerged from their analysis. The cluster of impri...

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Bibliographic Details
Published in:Trends in genetics 2008-06, Vol.24 (6), p.306-316
Main Authors: Rocha, Simao Teixeira da, Edwards, Carol A, Ito, Mitsuteru, Ogata, Tsutomu, Ferguson-Smith, Anne C
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromosomes, Human, Pair 14
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genetics of eukaryotes. Biological and molecular evolution
Genomic Imprinting
Humans
Intercellular Signaling Peptides and Proteins - chemistry
Intercellular Signaling Peptides and Proteins - genetics
Iodide Peroxidase - chemistry
Iodide Peroxidase - genetics
Mammals - genetics
Medical Education
Membrane Proteins - chemistry
Membrane Proteins - genetics
Mice
Models, Biological
Molecular and cellular biology
Molecular genetics
Protein Structure, Tertiary
Transcription. Transcription factor. Splicing. Rna processing
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Summary:Genomic imprinting causes genes to be expressed or repressed depending on their parental origin. The majority of imprinted genes identified to date map in clusters and much of our knowledge of the mechanisms, function and evolution of imprinting have emerged from their analysis. The cluster of imprinted genes delineated by the delta-like homolog 1 gene and the type III iodothyronine deiodinase gene (Dlk1-Dio3) is located on distal mouse chromosome 12 and human chromosome 14. Its developmental importance is exemplified by severe phenotypes associated with altered dosage of these genes in mice and humans. The domain contains three imprinted protein-coding genes, Dlk1 , Rtl1 and Dio3, expressed from the paternally inherited chromosome and several imprinted large and small noncoding RNA genes expressed from the maternally inherited homolog. Here, we discuss the function and regulation of imprinting at this domain.
ISSN:0168-9525
DOI:10.1016/j.tig.2008.03.011