Chemokines as novel therapeutic targets in inflammatory diseases

Chemokines and their receptors are a large family of inflammatory molecules responsible for a number of biological functions, including the accumulation of leukocytes at tissue sites. Over the past 10 years, a number of studies have indicated a role for chemokines and chemokine receptors in the path...

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Bibliographic Details
Published in:Biochemical pharmacology 2002-04, Vol.63 (7), p.1191-1196
Main Authors: Ajuebor, Maureen N., Swain, Mark G., Perretti, Mauro
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - metabolism
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Chemokine receptor antagonists
Chemokine receptors
Chemokines
Chemokines - metabolism
Drug Delivery Systems
Drug Design
Helicobacter Infections - metabolism
Humans
Inflammation
Inflammatory diseases
Leukocytes
Liver Diseases - metabolism
Medical sciences
Pharmacology. Drug treatments
Receptors, Chemokine - antagonists & inhibitors
Receptors, Chemokine - metabolism
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Summary:Chemokines and their receptors are a large family of inflammatory molecules responsible for a number of biological functions, including the accumulation of leukocytes at tissue sites. Over the past 10 years, a number of studies have indicated a role for chemokines and chemokine receptors in the pathophysiology of several inflammatory diseases, examples of which are multiple sclerosis, atherosclerosis, rheumatoid arthritis, and gastrointestinal diseases including hepatic disease. For this reason, it is not surprising that modulation of their pharmacology could be a prime target for drug discovery. This commentary provides a brief synopsis of our current knowledge of the role of chemokines and their receptors in the inflammatory process, and highlights the pros and possibly cons of chemokine and chemokine receptor antagonism in the therapeutic approach to several inflammatory diseases.
ISSN:0006-2952
1873-2968
DOI:10.1016/S0006-2952(02)00854-7