Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis

The aims of our study were to assess whether the increased oxidative stress in inflamed joints is reflected by serum lipid peroxidation and also to check alterations in the levels of extracellular antioxidants and antioxidant enzyme activities in patients with rheumatoid arthritis. Serum malondialde...

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Bibliographic Details
Published in:Rheumatology international 2002-03, Vol.21 (5), p.200-204
Main Authors: TAYSI, S, POLAT, F, GUL, M, SARI, R. A, BAKAN, E
Format: Article
Language:English
Subjects:
Adult
Aged
Antioxidants
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - physiopathology
Biological and medical sciences
Biomarkers
Ceruloplasmin - analysis
Ceruloplasmin - metabolism
Cohort Studies
Diseases of the osteoarticular system
Female
Glutathione Peroxidase - analysis
Glutathione Peroxidase - metabolism
Humans
Hydrogen peroxide
Inflammatory joint diseases
Linear Models
Lipid peroxidation
Lipid Peroxidation - physiology
Lipids
Male
Malondialdehyde - analysis
Malondialdehyde - blood
Medical sciences
Middle Aged
Oxidation
Probability
Prognosis
Prospective Studies
Rheumatoid arthritis
Sensitivity and Specificity
Severity of Illness Index
Superoxide Dismutase - analysis
Superoxide Dismutase - metabolism
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Summary:The aims of our study were to assess whether the increased oxidative stress in inflamed joints is reflected by serum lipid peroxidation and also to check alterations in the levels of extracellular antioxidants and antioxidant enzyme activities in patients with rheumatoid arthritis. Serum malondialdehyde and ceruloplasmin levels and the activity of CuZn superoxide dismutase were higher, while transferrin levels and the activities of glutathione peroxidase and catalase were lower in patients (n = 37) than in healthy controls (n = 30). Disease activity score correlated positively with serum malondialdehyde level and CuZn superoxide dismutase activity. Probably, superoxide radicals in serum could be dismutated to produce hydrogen peroxide by increased CuZn superoxide dismutase activity, but hydrogen peroxide could not have been detoxified due to decreased activities of serum glutathione peroxidase and catalase. Hydrogen peroxide possibly converted to hydroxyl radical by iron due to lower transferrin level might have led to increased serum lipid peroxidation in patients with rheumatoid arthritis.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-001-0163-x