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Structure activity relationships of quinoline-containing c-Met inhibitors
A series of quinoline-containing c-Met inhibitors were prepared and studied. Chemistry was developed to introduce a pyridyl moiety onto the 2-aryl ring present in a lead molecule which mitigated the potential for quinone formation relative to the original compound. The study also assessed the import...
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| Published in: | European journal of medicinal chemistry 2008-06, Vol.43 (6), p.1321-1329 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c390t-870b6947b436bc1a71f8f63d711b2252c17e0479fd58b8ce4e0535715a34738a3 |
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| cites | cdi_FETCH-LOGICAL-c390t-870b6947b436bc1a71f8f63d711b2252c17e0479fd58b8ce4e0535715a34738a3 |
| container_end_page | 1329 |
| container_issue | 6 |
| container_start_page | 1321 |
| container_title | European journal of medicinal chemistry |
| container_volume | 43 |
| creator | Kung, Pei-Pei Funk, Lee Meng, Jerry Alton, Gordon Padrique, Ellen Mroczkowski, Barbara |
| description | A series of quinoline-containing c-Met inhibitors were prepared and studied. Chemistry was developed to introduce a pyridyl moiety onto the 2-aryl ring present in a lead molecule which mitigated the potential for quinone formation relative to the original compound. The study also assessed the importance of an acylthiourea moiety present in the lead structure for effective binding to the c-Met protein ATP site.
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| doi_str_mv | 10.1016/j.ejmech.2007.08.011 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2008-06, Vol.43 (6), p.1321-1329 |
| issn | 0223-5234 1768-3254 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Antineoplastic agents Biological and medical sciences c-Met General aspects Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Pharmacology. Drug treatments Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-met - antagonists & inhibitors Quinoline Quinolines - pharmacology Structure-Activity Relationship |
| title | Structure activity relationships of quinoline-containing c-Met inhibitors |
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