Common Nonsynonymous Polymorphisms in the NOD2 Gene Are Associated with Resistance or Susceptibility to Tuberculosis Disease in African Americans

Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB)...

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Bibliographic Details
Published in:The Journal of infectious diseases 2008-06, Vol.197 (12), p.1713-1716
Main Authors: Austin, Celest M., Ma, Xin, Graviss, Edward A.
Format: Article
Language:English
Subjects:
Adult
African Americans - genetics
Alleles
Bacteria
Bacterial diseases
Biological and medical sciences
Biological resistance
Disease susceptibility
Female
Fundamental and applied biological sciences. Psychology
Fungal diseases
Fungal infections
Genetic Predisposition to Disease
Human bacterial diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Mycobacterium tuberculosis
Nod2 Signaling Adaptor Protein - genetics
Polymorphism, Genetic
Pulmonary tuberculosis
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Pulmonary - genetics
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Summary:Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms—Pro268Ser, Arg702Trp, and Ala725Gly—demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.
ISSN:0022-1899
1537-6613
DOI:10.1086/588384