Synthesis and turnover of folates in plants

Folates are essential cofactors for one-carbon transfer reactions, which are central to plant metabolism. Plants synthesize folates de novo, and are key sources of dietary folate for humans. Research into plant folates therefore impacts human nutrition. Biochemical progress, the sequencing of the Ar...

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Bibliographic Details
Published in:Current Opinion in Plant Biology 2002-06, Vol.5 (3), p.244-249
Main Authors: Hanson, Andrew D, Gregory III, Jesse F
Format: Article
Language:English
Subjects:
4-Aminobenzoic Acid - metabolism
Arabidopsis - genetics
Arabidopsis - metabolism
Biological Transport
Carbon-Nitrogen Ligases
compartmentation
Enzymes - genetics
Enzymes - metabolism
folate biosynthesis
folate metabolism
Folic Acid - metabolism
genomics
Glutamic Acid - metabolism
GTP Cyclohydrolase - metabolism
Plants - genetics
Plants - metabolism
Pteridines - metabolism
Tetrahydrofolates - chemistry
Tetrahydrofolates - metabolism
Transaminases - metabolism
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Summary:Folates are essential cofactors for one-carbon transfer reactions, which are central to plant metabolism. Plants synthesize folates de novo, and are key sources of dietary folate for humans. Research into plant folates therefore impacts human nutrition. Biochemical progress, the sequencing of the Arabidopsis genome, and EST databases are now painting a clear picture of the folate synthesis pathway in plants and its surprising compartmentation. Moreover, new analytical advances will help to elucidate plant folate turnover and transport, which are practically unexplored. Genomic approaches, biochemical progress, and analytical advances are facilitating the investigation of plant folates, which are key sources of folates in human diets.
ISSN:1369-5266
1879-0356
DOI:10.1016/S1369-5266(02)00249-2